Project Grant R03AG092563
- The National Institute on Aging, a division of the Department of Health and Human Services, awarded $506,198 to Ceiba Bio Inc. on September 15, 2025, under the Aging Research program (CFDA 93.866) to develop platelet-derived exercise mimetics as a treatment for Alzheimer's disease and Alzheimer's disease-related dementias. The award funds a fast-track Phase I to Phase II project translating prior research identifying exercise-induced platelet-derived factors in blood plasma that mediate...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded Duke University $1.597 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on epitranscriptomic regulation of microglia in Alzheimer's disease. The research investigates how m6a methylation of adenosine residues in messenger RNA regulates microglial cell function and transitions between resting and activated states during Alzheimer's disease pathogenesis, with the goal of identifying novel...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $154,960 to the University of Kansas Medical Center Research Institute, Inc. on February 26, 2026, under the Aging Research program (CFDA 93.866). The recipient will conduct research combining cellular and clinical measures to examine bioenergetic contributions to tau phosphorylation in aging and Alzheimer's disease. The work leverages existing clinical data from the KU...
- The National Institute on Aging awarded the University of Virginia $583,815 on August 15, 2026, under the Aging Research program (CFDA 93.866) to support research into oligodendrocyte lineage dysfunction during aging and Alzheimer's disease. The project aims to understand how myelin loss—a pathology common to both aging and Alzheimer's disease—develops in the central nervous system and to identify therapeutic targets for cognitive impairment. The research focuses on oligodendrocyte precursor...
- The National Institute on Aging, within the National Institutes of Health and the Department of Health and Human Services, awarded the University of California Irvine $739,365 on September 15, 2026, under the Aging Research program (CFDA 93.866, Project Grant R01AG098878) to develop and evaluate structure-guided active and passive beta-amyloid immunotherapies targeting early, non-fibrillar assemblies in Alzheimer's disease. The project develops vaccines and monoclonal antibodies directed against...
- The National Institute on Aging awarded the University of California, Berkeley $549,260 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop advanced large language model-based AI tools that enhance precision in predicting Alzheimer's disease pathology and cognitive outcomes. The research addresses critical gaps in precision medicine for Alzheimer's disease, particularly the need to capture patient heterogeneity, accurately identify treatment candidates for...
- The National Institute on Aging awarded The Leland Stanford Junior University $667,539 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research on mechanisms of brain repair during aging, with the objective of preventing Alzheimer's disease and Alzheimer's disease-related dementia. The research characterizes neural stem cells (NSCs) during injury and aging to identify interventions that boost repair in aging brains. NSCs reside in specific brain regions...
- The National Institute on Aging awarded $427,625 to The Washington University on September 1, 2026, under the Aging Research program (CFDA 93.866) to probe cerebellar cortex computations in Alzheimer's disease. The work examines cerebellar nodulus and uvula function in two Alzheimer's disease mouse models—APP/PS1 and 3XTG-AD—at 3, 6, and 12 months of disease progression to assess how hallmarks of Alzheimer's disease contribute to cerebellar dysfunction. The project tests the hypothesis that...
The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded $301,575 to the Palo Alto Veterans Institute for Research on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a two-year project grant testing the combined effectiveness of the anti-amyloid medication lecanemab and exercise training for Alzheimer's disease treatment. The recipient will use the 3XTG-AD mouse line to evaluate whether concurrent lecanemab therapy and exercise reduce Alzheimer's disease pathology and facilitate neural communication, with secondary aims to measure cognitive outcomes. The study addresses multiple dimensions of neurodegeneration—amyloid plaque accumulation, inflammation, and deficits in neural communication—hypothesizing that exercise enhances treatment efficacy by increasing brain-derived neurotrophic factor and regulating microglia activity. The research is performed at the Palo Alto, California facility with a period of performance from September 1, 2026, through August 31, 2028. The Aging Research program supports biomedical and behavioral research directed toward understanding the aging process and diseases affecting older populations, with particular emphasis on Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $301.6k | 8/14/26 |