RCT of an intersectional stigma intervention to sustain viral suppression among women living with serious mental illness and HIV in botswana

Ended Project Grant Awarded Last action

Award ID
R01TW012402
Recipient
Awarding agency
Obligated
$1,223,550

Award facts

Completion date
Originally
Place of performance
New York, USA

Award details come from USAspending.gov.

Description

Abstract
Reducing stigma to ensure viral load (VL) suppression for women with serious mental illness (SMI) and HIV is a global priority, including in botswana, where the intersectional stigma of SMI, HIV and womanhood is marginalizing in ways that impede adherence to both psychiatric medications and antiretroviral therapy (art), which can threaten VL suppression. We apply our novel 'what matters most' (WMM) approach to target intersectional stigma faced by women with SMI and HIV in botswana via a stigma-reduction intervention in the high-risk transition period after discharge from an initial psychiatric hospitalization. WMM conceptualizes how stigma is felt most acutely when people are unable to achieve 'full personhood' by participating in the activities that 'matter most' in their local context. In prior research, we found the core value for 'full womanhood' in botswana is achieved by being the 'foundation of the household' and is threatened by perceived: 1) incompetence in fulfilling the duties of a family caregiver associated with SMI and 2) promiscuity associated with having HIV. In botswana, family acceptance as a viable 'family caregiver' is also key to achieving 'full status' as a woman. As such, the risks of being identified as having SMI and HIV (e.g., partner/family abandonment) can deter psychiatric and art treatment adherence. Promoting capabilities that 'matter most' for achieving 'full womanhood' could enable longer-term stigma reduction after psychiatric discharge, when women are reintegrating into their communities, and improve art adherence and promote sustained VL suppression. Our group-based WMM stigma intervention is CO-led by a peer woman who has coped effectively with SMI and HIV stigma. The WMM stigma intervention model was piloted among pregnant women with HIV in botswana with promising reductions in stigma and depressive symptoms up to 4-months postpartum. We now test whether a WMM intervention tailored for women with SMI and HIV will reduce intersectional stigma and facilitate VL suppression. We propose a two-arm randomized controlled trial (RCT; n=180) with a 4-month follow-up to compare the effectiveness of 1) WMM-based intersectional stigma intervention delivered as clients transition from psychiatric hospitalization to outpatient care ('WMM stigma intervention;' n=90); and 2) attention control following a similar format to isolate the effects of the intervention (n=90). Because family are commonly involved in the care of people with SMI and face severe stigma, we propose a parallel, group stigma intervention among family members, as addressing familial stigma could facilitate treatment adherence. Finally, because intersectional stigma is reinforced at systemic levels, we seek to empower women with SMI and HIV to influence structural change by coleading policymaker workshops to reduce stigma among policymakers and spur policymakers to address the unique needs of women with SMI and HIV via future policies.

Transactions

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Amendment $194,299
Original award $194,299
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Subawards

Subrecipient Amount Awarded
University Of Botswana Project name: RCT of an intersectional stigma intervention to sustain viral suppression among women living with serious mental illness and HIV in Botswana… $250,957
The Trustees Of The University Of Pennsylvania Project Title: RCT of an intersectional stigma intervention to sustain viral suppression among women living with serious mental illness and HIV in Botswana… $113,748
The University Of British Columbia The following details the epigenetic analysis to be undertaken in the laboratories of Dr. Kobor pertaining to this application. DNA METHYLATION RESEARCH METHOD:… $49,680
The Trustees Of The University Of Pennsylvania Project Title: RCT of an intersectional stigma intervention to sustain viral suppression among women living with serious mental illness and HIV in Botswana… $75,832

Quick answers

Who received award R01TW012402?

R01TW012402 was awarded to New York University by Fogarty International Center (National Institutes of Health) on July 1, 2022.

How much is award R01TW012402 worth?

$1,223,550 has been obligated on R01TW012402.

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