The federal Project Grant award of $999,998.00 was awarded by the Agency for Toxic Substances and Disease Registry (ATSDR) under the State Capacity Building (CFDA 93.240) program. The grant supports a research project titled "Persistent Environmental Toxicants in Veteran CNS Tissue: Identifying Exposures Determining Higher ALS Risk." The goal is to investigate a panel of persistent environmental toxicant exposures in the central nervous system (CNS) tissue of military veterans as potential contributing factors to the development of amyotrophic lateral sclerosis (ALS). Dartmouth-Hitchcock Clinic, the prime awardee, will lead the project and collaborate with Columbia University and Dartmouth College as sub-awardees. Columbia University will develop and apply statistical methods to analyze the high-dimensional data collected from human brain samples, while Dartmouth College will provide data analysis on toxicant levels in various brain regions. This research aims to advance understanding of environmental exposures that may increase the risk of ALS among veterans, with the ultimate completion date set for Sep 29, 2027.
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