Project Grant R01NS151727
- Federal Project Grant Award Summary Colorado State University received a $2,674,385 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded August 15, 2025, with completion targeted for July 31, 2029. This research initiative investigates structure-function relationships in alpha-synuclein protein strains using cryo-electron microscopy (cryo-EM)...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $627,103 to the Research Foundation For Mental Hygiene, Inc. on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The Research Foundation For Mental Hygiene, Inc., operating through its New York State Psychiatric Institute division, will investigate the role of the adaptive...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $1.878 million to Mayo Clinic Jacksonville on September 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to interrogate alpha-synuclein aggregate-associated proteomes and identify modifiers of Lewy body disease. The project, running through August 31, 2029, employs...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $418,489 to the University of Florida on September 1, 2026, for exploration of potential treatments targeting alpha-synuclein in Parkinson's disease under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research to develop novel therapeutics for Parkinson's disease,...
- The National Institute of Neurological Disorders and Stroke, a division of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas Health Science Center at Houston $722,153 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing Project Grant R61NS151436). The recipient will develop and validate a seed amplification assay to detect alpha-synuclein...
- This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
- The National Institute of Neurological Disorders and Stroke awarded Colorado State University $496,279 on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate cholinergic synaptic homeostasis and the molecular mechanisms regulating compensatory changes in synaptic strength in response to altered neural activity. The recipient will use Drosophila as a genetically tractable model system to study central...
- The National Institute of Neurological Disorders and Stroke awarded Rush University Medical Center $1.212 million on June 25, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of alpha-synuclein phosphorylation in the synucleinopathy olfactory system. The research examines whether phosphorylated alpha-synuclein at serine 129 (PS129) drives early pathogenesis in synucleinopathies within the olfactory system...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $566,529 on April 24, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate age-related deficits in trophic support of dopamine neurons in preclinical models of Parkinson's disease. The research examines cell-type-specific alterations in LRRK2G2019S mice to determine how the LRRK2 mutation affects neuroprotective signaling...
- The National Institute of Neurological Disorders and Stroke awarded Rutgers The State University of New Jersey $617,246 on September 26, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the toxicity of lipid-rich alpha-synuclein inclusions in Parkinson's disease pathology. The research examines Lewy bodies and related lipid-rich alpha-synuclein inclusions prevalent in the substantia nigra and brainstem regions....
The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded Colorado State University $635,317 on September 3, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing R01NS151727) to investigate how fibril structure of alpha-synuclein strains affects disease pathogenesis in synucleinopathies. The research addresses disease heterogeneity arising from multiple alpha-synuclein strains co-existing in individual patients, including previously unidentified strains discovered in patient samples. The project examines distinct biological consequences of different alpha-synuclein conformations in central synucleinopathies—multiple system atrophy, Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies—to support development of diagnostics and therapeutics for synucleinopathy patients. Work is performed in Fort Collins, Colorado, with a period of performance through May 31, 2031. The award is classified as a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $635.3k | 9/3/26 |