Project Grant R01NS147102
- The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University $197,600 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program on September 30, 2025, to investigate state-dependent connectivity of impaired autonomic brain networks underlying cardiorespiratory dysfunction in epilepsy. The research integrates multimodal neuroimaging and electrophysiological data with cardiorespiratory activity measurements to...
- The National Heart, Lung, and Blood Institute awarded Regents of the University of Michigan $765,515 on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate neuro-cardiac mechanisms of sudden unexpected death in epilepsy. The research employs a transgenic rabbit model carrying SCN1A loss-of-function variants linked to Dravet syndrome to test the hypothesis that SCN1A haploinsufficiency drives sudden unexpected nocturnal death in epilepsy through cardiac...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded the University of California, Davis $548,368 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Assistance Listing designation). The project, "Slow-Wave Sleep Enhancement to Treat Epilepsy and Its Comorbidities" (R01NS147124), addresses the hypothesis that...
- The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $489,500 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to evaluate candidate genes for sudden unexpected death in pediatrics using zebrafish mutant larvae models. The research addresses the gap between genetic abnormalities identified in sudden unexpected infant death and sudden unexpected death in childhood cases and...
- The National Institute of Neurological Disorders and Stroke awarded Boston Children's Hospital $705,715 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct a multiomics investigation of sudden unexplained pediatric deaths. The research builds on Boston Children's Hospital's prior work in sudden unexpected death in pediatrics (SUDP) by integrating phenotypic and genetic data from the NIH/CDC Sudden Death in...
- The National Institute of Neurological Disorders and Stroke awarded the University of Virginia $565,250 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate microglial mechanisms in status epilepticus recovery. The research tests two hypotheses on how microglia facilitate seizure termination and recovery from prolonged seizures. Aim 1 investigates the role of microglial P2RY12 receptor inhibition of...
- The National Institute of Neurological Disorders and Stroke awarded Vanderbilt University Medical Center $688,785 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate arousal network dysfunction in temporal lobe epilepsy. The research examines how recurrent consciousness-impairing focal seizures in temporal lobe epilepsy patients affect subcortical arousal networks and contribute to long-term...
- The National Institute of Neurological Disorders and Stroke awarded the College of William & Mary $234,375 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate monosynaptic connections between the amygdala and the prebotzinger complex that may control breathing inhibition. The project examines how central amygdala GABAergic neurons exert inhibitory control over the prebotzinger complex, the...
- The National Institute of Neurological Disorders and Stroke awarded The Regents of the University of Colorado, doing business as University of Colorado-Denver, $473,860 on May 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate heterosynaptic mechanisms driving elevated synaptic inhibition and plasticity impairments following cardiac arrest-induced global cerebral ischemia. The research explores how GABAergic...
- The National Institute of Neurological Disorders and Stroke awarded the University of Virginia $459,143 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate a mouse model of temporal lobe epilepsy suitable for drug screening. The funded work addresses the lack of animal models amenable to pharmaceutical testing for temporal lobe epilepsy, a debilitating disorder affecting millions worldwide. The...
The National Institute of Neurological Disorders and Stroke awarded Creighton University $497,267 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate mechanisms of autoresuscitation failure in sudden unexpected death in epilepsy (SUDEP). The research project, titled "Chronic Stress Increases the Probability of Autoresuscitation Failure in Preclinical SUDEP," addresses a gap in understanding why approximately 30 percent of individuals with refractory epilepsy fail to spontaneously recover breathing after seizure-induced hypoxic and hypercapnic blood gas fluctuations. The central hypothesis tests whether chronic stress increases the probability of autoresuscitation failure by promoting maladaptive modulatory control of brain regions and circuitries critical for successful recovery. The project will use two clinically relevant animal models of SUDEP to delineate mechanisms driving autoresuscitation failure, with findings intended to inform risk assessment and identify therapeutic opportunities. The period of performance runs from September 1, 2026, through August 30, 2031. Work is performed in Omaha, Nebraska.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $497.3k | 8/24/26 |