Project Grant R01NS143992
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Brigham & Women's Hospital $230,580 on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct investigator-initiated research on circuit-based deep brain stimulation (DBS) reprogramming for cognitive impairment in Parkinson's disease patients. The research addresses cognitive decline that may follow DBS surgery, a common and effective...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $635,512 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate an automated deep brain stimulation programming platform for patients with Parkinson's disease. The project will develop machine learning algorithms and a closed-loop automated system to optimize deep brain stimulation parameters—including contact...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $469,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Michigan Technological University. The grant, titled "Dissecting Neural Circuit Mechanisms Underlying Pallidal Deep Brain Stimulation," will fund research to identify the neural elements and circuits necessary for the therapeutic effects of deep brain stimulation (DBS) of the globus...
- The National Institute of Neurological Disorders and Stroke awarded $597,934 to The University of Texas Southwestern Medical Center on March 22, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to dissect the network physiology of pallidal burst stimulation for Parkinson's disease deep brain stimulation (DBS) therapy. The recipient will analyze basal-ganglia-thalamo-cortical motor circuits through intracranial recordings of...
- The National Institute of Neurological Disorders and Stroke awarded the University of Pittsburgh a cooperative agreement totaling $312,858 on September 1, 2026, to test the safety, feasibility, and early efficacy of deep brain stimulation of the motor thalamus to improve speech intelligibility in people with chronic post-stroke dysarthria. The award funds research under the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The project will...
- The National Institute of Neurological Disorders and Stroke awarded New York Medical College $162,400 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to evaluate deep brain stimulation targeting the paraventricular hypothalamic nucleus and arcuate nucleus as a novel therapeutic strategy for refractory infantile epileptic spasms syndrome in a validated rat model. The research will test proof-of-principle efficacy of...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $540,901 on April 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate molecular mechanisms underlying dopamine signaling dysfunction in advanced Parkinson's disease. The research examines how striatal projection neurons become maladaptive during disease progression and why L-DOPA therapy loses efficacy over time. The work focuses...
- The National Institute of Neurological Disorders and Stroke awarded The Cleveland VA Medical Research & Education Foundation $572,132 on August 22, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to design and test a prototype noninvasive electrical stimulation device and determine its effect on bladder control for women with spinal cord injury–related neurogenic bladder dysfunction. The project targets bladder hyperreflexia,...
- The National Institute on Aging awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University $2.65 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate neural mechanisms underlying the benefits of aerobic exercise in advanced Parkinson's disease. The funded research enrolls 51 advanced people with Parkinson's disease who have subthalamic nucleus deep brain stimulation and randomizes them equally to three arms: voluntary exercise...
- The National Institute of Neurological Disorders and Stroke awarded Emory University $618,523 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on September 1, 2026, for research on scalable, affordable artificial intelligence-driven clinical decision support for movement disorders. The project addresses misdiagnosis and access barriers in Parkinson's disease care, particularly the underdiagnosis of psychiatric symptoms and limited...
The National Institute of Neurological Disorders and Stroke awarded The Cleveland VA Medical Research & Education Foundation $330,000 on August 7, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate subthalamic deep brain stimulation for resolving visuo-vestibular conflict in Parkinson's disease. The research aims to optimize subthalamic nucleus DBS to enhance self-motion perception and visuo-spatial navigation in Parkinson's disease patients while maintaining effectiveness on motor symptoms. The work employs psychophysics, virtual reality, motion analysis, neuroimaging, and computational modeling to investigate visuo-vestibular interactions and how STN DBS improves perception during visual-vestibular conflicts. Clinical assessments include functional gait assessment, gait disorientation task, gait speed, and motor symptom evaluation using UPDRS-III. Aim 1 examines how the location of tissue activation within the STN affects heading perception during visuo-vestibular conflict using a motion simulator and virtual reality, combined with development of a stimulation atlas identifying STN locations linked to changes in heading perception. Aim 2 identifies which axonal pathways modulated by STN DBS correlate with improved heading perception. Performance occurs in Cleveland, Ohio. The period of performance runs through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $330.0k | 8/7/26 |