Novel neurosurgical device for evacuation of intracerebral hematoma

Active Project Grant Awarded Last action

Award ID
R01NS143100
Recipient
Awarding agency
Obligated
$1,072,800

Award facts

Completion date 27% complete
Place of performance
Irwindale, CA 91010, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Spontaneous supratentorial intracerebral hemorrhage (ICH) affects nearly 67,000 patients every year in the US and is associated with a 35-50% mortality rate within a month of occurrence. In addition to preventive measures and medical management, surgery continues to be an important part of treatment for such patients. Currently, removal of ICH from the brain is accomplished through a craniotomy, or large skull opening. For most large hematomas that come to the surface of the brain, this technique is effective in providing adequate surgical exposure to remove the mass and to obtain hemostasis. A craniotomy, however, is time consuming and retraction of the brain during these operations can result in brain injury. Furthermore, large craniotomies can contribute to postoperative morbidity, such as pain and wound-related complications. Development of less invasive techniques and methodology will minimize these risks and patient discomfort. Moreover, minimally invasive techniques may have socio-economic value by reducing operative and postoperative recovery time, especially for an elderly patient population with multiple medical CO-morbidities. Current minimally invasive technologies, however, result in variable ICH evacuation rates and have limited efficacy in removing deeply located basal ganglia hematomas. Thus, neurosurgical devices that enable rapid and consistent hematoma evacuation, irrespective of ICH location, are needed. The goal of this project is to fabricate and determine the feasibility of a novel instrument (termed "remide") that can efficiently and consistently remove an ICH using image-guided, minimally invasive techniques. Our initial studies using proof-of-concept prototypes that we designed and fabricated have demonstrated the feasibility of the approach. Our robotic device creates a cavity in the brain through a

Transactions

Action Obligated Date
Amendment $633,561
Original award $439,239

Subawards

Subrecipient Amount Awarded
Loma Linda University The consortium consists of researchers from City of Hope (COH), University of California, Riverside (UCR), and Loma Linda University (LLU). COH will be the lead… $249,551
The Regents Of The University Of California Tasks to be performed for this project by University of California, Riverside (UCR): In Year 1, UCR will collaborate with City of Hope (COH) to design and… $528,819

Quick answers

Who received award R01NS143100?

R01NS143100 was awarded to Beckman Research Institute Of The City Of Hope by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on July 1, 2025.

How much is award R01NS143100 worth?

$1,072,800 has been obligated on R01NS143100.

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