Project Grant R01NS140765
- This Project Grant award of $704,313 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to advance a prognostic and monitoring biomarker of neutrophil-driven secondary brain injury in spontaneous intracerebral hemorrhage. The primary objective is to define and validate a standardized protocol to detect specific neutrophil biomarker levels as a potential prognostic and...
- This $537,508 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to understand the role of endogenous zinc protoporphyrin (ZnPP) in intracerebral hemorrhage (ICH)-induced brain damage. The research aims to elucidate the mechanisms by which ICH triggers ZnPP formation and how ZnPP contributes to neurotoxicity, as well as evaluate...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the J. David Gladstone Institutes in California. This grant funding supports a multidisciplinary research program to study the role of neurovascular dysfunction in neurodegeneration, CNS repair, and glial cell biology. Key research activities include in vivo two-photon and super-resolution...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support metabolomic research related to intracerebral hemorrhage (ICH) recovery. The $669,092 award, with a period of performance from May 2025 to April 2029, will leverage samples and data from two large genetic epidemiology studies of ICH to assess 5,400 metabolites and identify...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $226,112 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Colorado-Denver. The grant is focused on leveraging sex differences to understand the brain's macrophage immune response to perinatal hypoxic ischemic encephalopathy (HIE), a leading cause of death and disability in newborns. The research aims to determine the primary...
- This $540,236 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is funding research to target the RNA regulator HuR in order to suppress inflammation and promote neuroprotection in acute ischemic stroke. The University of Alabama at Birmingham is the primary awardee and will conduct preclinical studies to investigate the...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
- This Project Grant award of $438,625.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at the University of California, San Diego (UCSD) to characterize and augment a novel pro-survival mechanism in neurons during ischemic brain injury. The research aims to investigate the role of the protein INF2 in driving "actinification", a...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $373,778 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Research Foundation For The State University Of New York (Stony Brook University) to establish a novel vasculature database and analytical platform for mouse brain vasculature. The project aims to develop topology-preserving vessel segmentation algorithms and advanced statistical models...
- This $2,503,949 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rockefeller University aimed at discovering therapeutic targets for neurological diseases. The project utilizes new techniques and concepts to study the fundamental mechanisms of brain disorders, focusing on how differences in cell-specific RNA regulation contribute to...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $671,988 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Winifred Masterson Burke Medical Research Institute, Inc. The project focuses on understanding the cross-talk between two cell death pathways, sarmoptosis and ferroptosis, in the context of intracerebral hemorrhage (ICH), a type of stroke. The research aims to explore how the accumulation of red blood cell byproducts like hemoglobin and hemin following ICH can lead to axonal degeneration through these cell death mechanisms. The grant was awarded on September 11, 2025 with an ultimate completion date of July 31, 2030. The Burke Medical Research Institute, a non-profit organization focused on neurological research, will conduct this advanced neuroscience investigation as the prime awardee.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $672.0k | 9/11/25 |