This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $454,717 over a 5-year period beginning July 1, 2024 to study how the three-dimensional organization of the genome in neural progenitor cells (neuroblasts) contributes to gene expression and cell identity in the developing brain. The research aims to: 1) Profile genome-wide chromatin interactions in neuroblasts at different...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,008,977.00 to support research on the developmental topology of the human cerebral cortex. The key objectives are to improve understanding of human brain development and the origins of neurodevelopmental diseases by studying neural progenitor cell types in the outer...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $242,310 to Baylor College of Medicine to study the effects of the NR2E1 gene mutation on neurogenesis and its impact on human brain development and function. The research aims to: 1) assess how the I385T mutation in the NR2E1 gene affects its ability to interact with...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,282,359.00 to the Regents of the University of Michigan to conduct research on the regulation of intermediate progenitor cells during neural development. The project aims to define the mechanisms that control the competency of neural stem cells to generate intermediate...
This $460,940 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program aims to investigate the impact of glioma-associated germline risk alleles on neurodevelopmental trajectories. The research focuses on elucidating the epigenetic and transcriptional mechanisms by which two specific glioma-associated risk SNPs, rs7572263 and rs78378222, dysregulate...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $2,503,949.00 to Rockefeller University for a research project titled "Applying RNA Logic in Space and Time to Neurologic Disease." The project aims to develop new techniques and concepts to discover therapeutic targets for neurological diseases. Key focus areas include...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $619,474 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the role of the cohesin protein complex in regulating gene expression and neural development in the mammalian brain. The 5-year project aims to leverage the protocadherin...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $397,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program to the Massachusetts Institute of Technology (MIT). The grant, effective May 1, 2025 through April 30, 2030, will support innovative research to study fundamental principles linking neurodevelopmental processes to the functional organization of neural circuits. The goal is to...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $504,175 to Yale University to conduct research on the role of non-coding RNA in the regulation of pluripotent stem cell biology and differentiation. The research program leverages the in vivo study of adult pluripotent stem cells in the planarian Schmidtea mediterranea to investigate how piwi-interacting RNAs (piRNAs) and...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $234,949 to Yale University to conduct research on mechanisms that support raphespinal tract plasticity and regeneration after spinal cord injury. The objectives are to use anatomy, spatial transcriptomics, and intersectional in vivo chemogenetics to define the capacity and...