This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $532,381 to Emory University to comprehensively investigate the molecular mechanisms underlying the role of the KIF5A gene variant KIF5ADE27 in the pathogenesis of amyotrophic lateral sclerosis (ALS). The research aims to determine the gain-of-function effects of KIF5ADE27 in...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research to understand the role of the PASK kinase in regulating autophagy and its effects on spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). The $1,504,638 award, granted on September 19, 2024, will enable...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $2,307,075 to The Leland Stanford Junior University to support an ambitious research program aimed at defining novel mechanisms of human neurodegenerative diseases and translating those findings into potential new therapies. The key products and services to be delivered...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will provide $397,839 over 5 years to support research at the University of Texas Health Science Center at San Antonio. The research aims to delineate the mechanisms by which the tubulin polymerization promoting protein (TPPP) interacts with mitochondrial proteins and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research to identify mechanisms of neurofilament regulation and turnover in amyotrophic lateral sclerosis (ALS). The $558,182 award to The Washington University in St. Louis will support the development of proteomic assays to analyze neurofilament isoforms and...
This $645,391 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, will fund research to investigate the effects of re-expressing embryonic motor neuron selector transcription factors ISL1 and LHX3 in mouse models of amyotrophic lateral sclerosis (ALS) and in induced pluripotent stem cell-derived ALS motor neurons. The goal is to examine whether restoring the expression of these factors in mature motor...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $461,900.00 to Pennsylvania State University's Milton S. Hershey Medical Center to study the mechanisms by which the protein TDP-43 impacts muscle structure and function in amyotrophic lateral sclerosis (ALS) and related neuromuscular disorders. The research aims to identify TDP-43 translation targets in Drosophila muscle models and validate the findings in patient tissues, with the goal of...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is supporting the development and optimization of a new animal model for Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The $374,349 award to the University of North Carolina at Chapel Hill aims to demonstrate the progressive ALS/FTD-like phenotype in aged cohorts of...
This federal Project Grant award, issued by the Department of the Army Medical Command under the Military Medical Research and Development program (CFDA 12.420), provides $2,905,936.00 to The Trustees of the University of Pennsylvania for a pilot randomized clinical trial of early ventilation in amyotrophic lateral sclerosis (ALS). The award supports the university's research capabilities in neuroscience and biomedical sciences to advance the understanding and treatment of neurological...
This Project Grant award, with ID K99NS140635, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The $121,554 award supports research to investigate the impact of KIF5A gene mutations on RNA processing and their role in the development of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease. The research objectives include...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $1,373,307 in funding to The University of Texas Permian Basin (UTPB) from Jul 1, 2024 to May 31, 2029. The project aims to investigate the molecular mechanisms by which the mitochondrial carrier protein PSAP contributes to the pathogenesis of amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disorder. The research leverages UTPB's expertise in cellular and animal models to elucidate how PSAP regulates both apoptosis and autophagy processes, which are dysregulated in ALS. The goal is to identify new therapeutic targets for treating ALS and other neurodegenerative diseases.