Developing multi-CUE piezoelectric pvdf-trfe biomaterials for peripheral nerve repair

Active Project Grant Awarded Last action

Award ID
R01NS134804
Recipient
Awarding agency
Obligated
$3,431,306

Award facts

Completion date 56% complete
Place of performance
Cincinnati, OH 45221, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Peripheral nervous system (PNS) injuries impact millions of americans each year with approximately 20 million people currently living with the effects of such injury. In the case of severe injuries, nerve pathways, connections, and the extracellular matrix (ECM) surrounding the nerve that lead to the distal innervation targets are disrupted. If the injury GAP is large enough, functional recovery is extremely limited and adequate clinical therapies DON't exist. A key reason for poor functional recovery is that neurons lack the proper guidance, alignment, and signaling from the damaged ECM to allow for targeted growth across injured tissue. Therefore, our overarching goal is to develop an ultrashock-mediated, bioactive scaffold to address traumatic PNS injury. The scaffold will possess controllable electrical, physical, and chemical signaling capabilities to address guidance, alignment, and cell-ECM communication. Piezoelectric poly(vinylidene fluoride-CO-trifluoroethylene)(pvdf-trfe) is integrated with decellularized ECM and capable of producing controllable electrical stimulation in response to remote ultrashock activation without the need for electrodes due to its piezoelectric capacity. The studies proposed will focus on quantitatively determining and controlling the electric potential of the scaffolds due to ultrashock and mechanical stimulation (aim 1), analysis of the integration and phenotypic response of schwann cells to pvdf-trfe scaffolds (aim 2), and the ability of the scaffold to minimize immune response while evaluating the ability to repair critical sized nerve gaps in vivo (aim 3).

Transactions

Action Obligated Date
Amendment $46,074
Amendment $414,682
Amendment $414,682
Amendment $410,896
Amendment $410,896
Amendment $410,896
Amendment $0
Amendment $0
Amendment $441,060
Amendment $441,060
Original award $441,060
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Subawards

Subrecipient Amount Awarded
Cincinnati Education & Research For Veterans Foundation, Inc. DBA Cerv Amend 1 - Developing multi-cue piezoelectric PVDF-TrFE biomaterials for peripheral nerve repair $14,201
Cincinnati Education & Research For Veterans Foundation, Inc. DBA Cerv Developing multi-cue piezoelectric PVDF-TrFE biomaterials for peripheral nerve repair $6,095

Quick answers

Who received award R01NS134804?

R01NS134804 was awarded to Cincinnati Univ Of by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on January 1, 2024.

How much is award R01NS134804 worth?

$3,431,306 has been obligated on R01NS134804.

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