The contribution of the oral microbiome to alzheimer?s disease risk
Active Project Grant Awarded Last action
- Award ID
- R01NS133809
- Recipient
-
Emory University UEI S352L5PJLMP8
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,137,564
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date 55% complete
- Originally
- Funding agency
- National Institute on Aging National Institutes of Health, Department of Health and Human Services
- Place of performance
- Atlanta, GA 30322, USA
Award details come from USAspending.gov.
Description
- Abstract
- Alzheimer's disease (ad) affects 6.5 million americans inflicting tremendous burden on our society both economically and in terms of human suffering, yet the etiology of ad is not fully understood. Risk factors for ad are numerous and include demographic, genetic, lifestyle, medical, environmental, psychiatric, and infectious factors. Among the infectious factors known to be associated with ad is periodontal disease (period). Period is a polymicrobial infection of the gingival tissue and one of the most common conditions of the oral cavity. There is a growing interest in the connection between period and ad, yet the mechanism between underlying this association is unknown, and most studies have focused their investigation on a limited number of period- associated organisms, for example porphyromonas gingivalis, tanerella forsythia, and treponema denticola. Currently, a major and fundamental obstacle in the field is the lack of a cross-kingdom (bacterial, viral, fungal), comprehensive characterization of the oral microbiome of period as IT relates to ad risk. The overall purpose of the proposed project is to investigate the clinical relevance of the oral microbiome in individuals most at risk for ad. 150 middle aged individuals will be enrolled in this longitudinal cohort study. The main objective is to characterize the taxonomy and function of oral bacteria, viruses and fungi among cognitively normal individuals at risk for ad, and over a two-year period, investigate relationships among period-associated microbiome features, inflammation, social determinants of oral health, and ad CSF biomarkers (ASS42, total-TAU, and phospho-TAU). We will leverage existing NIH funded, well-characterized cohorts that include racially diverse individuals at high risk for ad (through family history or APOE4 allele). Participants will complete 3 study visits annually. Cerebral spinal fluid for ad and inflammatory markers will be collected at baseline and YR2. Annual assessments and specimen collection will include: a clinical oral examination; subgingival plaque for microbiome assessment; saliva for inflammatory markers; blood for systemic inflammatory markers; neuropsychological testing; and surveys (medication/health history; oral symptoms, hygiene behavior, and quality of life; social determinants of health). Finally, we will conduct semi-structured in-depth interviews to explore the social determinant factors related to oral health and ad. Generated data will inform larger NIH funded studies and, to our knowledge, provide the largest and most comprehensive characterization of the oral microbiome in a racially diverse sample of individuals at risk for ad.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $774,368 | |
| Amendment | $0 | |
| Amendment | $774,536 | |
| Amendment | $794,330 | |
| Original award | $794,330 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The Research Foundation For The State University Of New York | $55,861 | |
| The Research Foundation For The State University Of New York | $28,566 | |
| The Research Foundation For The State University Of New York | $28,402 | |
| The Research Foundation For The State University Of New York | $28,152 |
Quick answers
Who received award R01NS133809?
R01NS133809 was awarded to Emory University by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on September 12, 2023.
How much is award R01NS133809 worth?
$3,137,564 has been obligated on R01NS133809.
Which agency awarded R01NS133809?
National Institute of Neurological Disorders and Stroke (National Institutes of Health) awarded R01NS133809, with funding from National Institute on Aging (National Institutes of Health).
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