Legennds: linking epidemiology and genetics of neurodevelopmental and neurodegenerative disorders study

Active Project Grant Awarded Last action

Award ID
R01NS131433
Recipient
Awarding agency
Obligated
$2,391,116

Award facts

Completion date 58% complete
Originally
Place of performance
Pennsylvania, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Emerging evidence suggests that certain neurodevelopmental disorders - autism (ASD), attention-deficit hyperactive disorder (adhd), and intellectual disability (ID) - may increase risk of later life neurodegenerative disorders such as alzheimer's disease or related dementia (adrd), parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). We propose a multinational study of epidemiological and genetic data across the countries of sweden, denmark, and the UK to characterize the natural history (aim 1) and familial aggregation (aim 2) of these disorders. We also explore genetic links (aim 3) between neurodevelopmental and later life neurodegenerative disorders, and identify potential targets for intervention that may mitigate risk (aim 4). Our study will use data from 10+ million persons from sweden and denmark with decades of follow-up; ipsych, an extensively genotyped case-cohort with ~25,000 ASD, ~30,000 adhd cases, and 50,000 controls; and a prospective cohort of older adults from the UK (UK biobank) totaling over half a million persons. Our analytic approach links epidemiological and genetic data, that together, triangulate to answer the question of whether ASD, adhd, and ID increase risk of adrd, PD, and ALS.

Transactions

Action Obligated Date
Amendment $0
Amendment $181,960
Amendment $126,667
Amendment $184,670
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $501,714
Amendment $139,683
Amendment $0
Amendment $0
Amendment $141,170
Original award $665,524
Show all 15

Subawards

Subrecipient Amount Awarded
University Of Pittsburgh - Of The Commonwealth System Of Higher Education The University of Pittsburgh has a collaborative role with Drexel University in the proposed study. The aims of the study are as follows: Aim 1 - Natural… $13,327
Karolinska Institutet Dr. Fang, together with Dr. Gardner, will oversee a postdoctoral scientist, a PhD student, a statistician, and a research administrator. She will supervise… $55,596
Rush University Medical Center Rush University has a collaborative role with Drexel University in the proposed study. The aims of the study are as follows: Aim 1 – Natural history:… $6,270
Karolinska Institutet The Karolinska Institutet has a collaborative role with Drexel University in the proposed study. The aims of the study are as follows: Aim 1 – Natural… $181,960
University Of Pittsburgh - Of The Commonwealth System Of Higher Education The University of Pittsburgh has a collaborative role with Drexel University in the proposed study. The aims of the study are as follows: Aim 1 – Natural… $26,654
Rush University Medical Center Bryan D. James, PhD, Sub PI, 0.6 calendar month effort in years 1-5: Dr. James, Associate Professor of Internal Medicine, is an Epidemiologist at the Rush… $24,556
Aarhus Universitet PI: Jakob Grove, PhD Aarhus University has a collaborative role with Drexel University in the proposed study. The aims of the study are as follows: Aim 1 –… $126,668
Aarhus Universitet PI: Jakob Grove, PhD Aarhus University has a collaborative role with Drexel University in the proposed study. The aims of the study are as follows: Aim 1 –… $130,178
Karolinska Institutet The Karolinska Institutet has a collaborative role with Drexel University in the proposed study. The aims of the study are as follows: Aim 1 – Natural… $181,960

Quick answers

Who received award R01NS131433?

R01NS131433 was awarded to Drexel University by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on May 1, 2023.

How much is award R01NS131433 worth?

$2,391,116 has been obligated on R01NS131433.

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