Project Grant R01NS129984

Award Date 8/20/24
Completion Date 6/30/29
Dollars Obligated $1.6M
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30322, USA
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This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to deepen the understanding of how deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) suppresses seizures in patients with drug-resistant epilepsy. The total award amount is $1,569,716.00 over the project period from August 20, 2024 to June 30, 2029.

The research aims to identify the specific neuronal network components and mechanisms by which ANT-DBS exerts its therapeutic effects, using a mouse model of temporal lobe epilepsy. Key focus areas include determining the role of ANT neurons, the ANT-retrosplenial cortex pathway, and afferent inputs to the ANT, such as from the mammillary bodies. This work could lead to more targeted device placement, improved patient selection, and novel seizure-suppressing therapies. Emory University is the prime awardee, with Rutgers, The State University of New Jersey receiving a $125,199 subaward to contribute to this research.

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