Cerebral autoregulation, brain perfusion, and neurocognitive outcomes after traumatic brain injury (capcog-TBI)

Active Project Grant Awarded Last action

Award ID
R01NS129934
Recipient
Awarding agency
Obligated
$6,223,910

Award facts

Completion date 66% complete
Place of performance
Dallas, TX 75390, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Traumatic brain injury (TBI) is a leading cause of disability in adults and the quality of life of TBI survivors is highly dependent on the adequacy of cognitive recovery. TBI is also a risk factor for alzheimer's disease (ad) and ad-related dementias (adrd). Mounting evidence indicates that cerebrovascular dysfunction occurs in both TBI and ad/adrd and can be a cross-link between the two diseases. The 2019 adrd summit called for further studies to understand vascular contributions to progressive cognitive impairment/dementia associated with TBI and develop non-invasive diagnostic APPROACHES5,9. The following important knowledge gaps exist: 1) what is the impact of early cerebrovascular dysfunction after TBI on short and long-term cognitive outcomes after accounting for age, SEX, and pre-existing health conditions? 2) what is the temporal relationship between the cerebrovascular function recovery and cognitive outcome after TBI? And 3) is there a relationship between cerebrovascular dysfunction and post-TBI neurodegeneration? The overarching goal of this proposal is to determine whether acute cerebrovascular dysfunction and its recovery within the first year postinjury are associated with cognitive outcomes and neurodegeneration 12 months after moderate to severe TBI (mstbi). Our central hypothesis is that cerebrovascular function measured by dynamic cerebral autoregulation (CA) and brain perfusion during acute stage and its recovery during the first year are inversely associated with cognitive outcomes and brain volume loss at 12 months postinjury. We propose a longitudinal study with 100 adults who sustained a single mstbi and 30 controls with non-TBI orthopedic trauma in the first week after the initial injury. We will follow them at 3 months, 6 months, and 12 months after injury. The primary outcome will be the NIH toolbox cognitive battery fluid composite score supplemented with sensitive episodic memory and processing speed measures at 12 months postinjury. To address the overarching goal, we aim to 1) determine the association of cerebrovascular dysfunction during the acute stage of mstbi (

Transactions

Action Obligated Date
Amendment $1,151,263
Amendment $245,516
Amendment Blood-based ad biomarkers profile in capcog-TBI study - sustaining a traumatic brain injury (TBI) can lead to an onset of and/or accelerate alzheimer's… $1,161,635
Amendment $1,146,429
Amendment $0
Amendment $0
Amendment $839,689
Amendment $839,689
Original award $839,689

Subawards

Subrecipient Amount Awarded
Albert Einstein College Of Medicine Will be responsible for imaging aspect of this project, including data acquisition protocol development and implementation, image quality assurance, image… $596,049
Texas Health Presbyterian Hospital Dallas Because of the unique relationship between the Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas and the University… $982,483

Quick answers

Who received award R01NS129934?

R01NS129934 was awarded to The University Of Texas Southwestern Medical Center by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on September 1, 2023.

How much is award R01NS129934 worth?

$6,223,910 has been obligated on R01NS129934.

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