Structural and functional imaging markers in degenerative cervical myelopathy

Active Project Grant Awarded Last action

Award ID
R01NS129852
Recipient
Awarding agency
Obligated
$2,319,504

Award facts

Completion date 64% complete
Place of performance
Oklahoma City, OK 73104, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Degenerative cervical myelopathy (DCM) is the most common cause of spinal injury in patients over 55 years of age. IT has a profound health care impact, leading to more than 100,000 operations a year and upwards of $2 billion in health care expenditure. Unfortunately, traditional cervical spine MRI techniques are imperfect predictors of ongoing spinal injury and cannot predict which patients will respond well to intervention. Further, there is a critical GAP in our understanding of how the spinal cord is injured during ongoing degenerative compression. The application of new imaging technologies may help close this GAP. Our previous work, during K23 studies, has shown the utility of both white matter (WM) imaging markers and spinal cord morphometrics for monitoring ongoing injury as well as predicting recovery. The development of tract-specific WM imaging methods, as proposed in this work, may aid in translating these findings to clinical care. Further, our work shows the volume of the cervical cord gray matter (GM) is decreased in DCM. Utilizing a novel spinal cord fmri methodology, we have additionally seen decreased GM activation in DCM patients, a change that associates with patient symptoms. These findings challenge the traditional view that DCM is a disease primarily of the WM. An objective of our proposed studies is to utilize a newly developed consensus spine imaging protocol to substantiate the role of WM markers in tracking spinal injury, a critical next step in the translation of these imaging results. Further, we develop a new fmri methodology that is used to show that GM activity is decreased in the injured cord. Our central hypothesis is that while markers of WM injury are the leading predictor of symptoms of neural injury in DCM patients, GM injury also plays a key role in each patient's clinical symptoms. We will test this hypothesis by developing new tract specific markers and novel spinal fmri methodology. Building upon our previous experience, we will compare the alterations of both WM and GM markers in these patients, with the goal of enhancing our ability to accurately predict both ongoing injury and early recovery after surgery. These findings will have a significant positive impact on human health by providing new understanding of the drivers of spinal injury in degenerative cervical compressive disease and developing new markers of injury that may enhance our ability to monitor and treat injury as well as prognosticate recovery.

Transactions

Action Obligated Date
Amendment $585,406
Amendment $592,231
Amendment $520,747
Original award $621,120

Subawards

Subrecipient Amount Awarded
The University Of Texas Southwestern Medical Center He is a faculty member at the rank of tenured Professor and a R. Wofford Cain distinguished chair in the department of physical medicine and rehabilitation, and… $125,424
Laureate Institute For Brain Research, Inc. The work to be performed by the Laureate Institute for Brain Research (LIBR) for the University of Oklahoma (OU) is as follows: 1) LIBR will scan 30 healthy… $43,332
University Of Oklahoma This subaward to the University of Oklahoma covers the efforts of Dr. Ding and a PhD student in years 2 to 5 from Norman campus on this grant, mainly related to… $88,944
The Leland Stanford Junior University The R0l subaward to the Stanford University will cover the efforts of Drs. Mackey and Weber on this proposal. Dr. Mackey is the Redlich Professor in the… $44,021
The Leland Stanford Junior University The R01 subaward to the Stanford University will cover the efforts of Drs. Mackey and Weber on this proposal. Dr. Mackey is the Redlich Professor in the… $34,840
University Of Oklahoma This subaward to the University of Oklahoma covers the efforts of Dr. Ding and a PhD student in years 2 to 5 from Norman campus on this grant, mainly related to… $116,677
Laureate Institute For Brain Research, Inc. 1. The LIBR MRI Facility will provide MRI scanning based upon approved OUHSC protocol for 40 total subjects, including healthy controls (HC), during the project… $42,181
The University Of Texas Southwestern Medical Center Dr. Dhaher joined UTSW medical center in 2018. He is a faculty member at the rank of tenured Professor and a R. Wofford Cain distinguished chair in the… $142,862
University Of Oklahoma This subaward to the University of Oklahoma covers the efforts of Dr. Ding and a PhD student in years 2 to 5 from Norman campus on this grant, mainly related to… $98,158
The University Of Texas Southwestern Medical Center Dr. Dhaher joined UTSW medical center in 2018. He is a faculty member at the rank of tenured Professor and a R. Wofford Cain distinguished chair in the… $122,189
Laureate Institute For Brain Research, Inc. The work to be performed by the Laureate Institute for Brain Research (LIBR) for the University of Oklahoma (OU) is as follows: 1) LIBR will scan 30 healthy… $42,181
Show all 11

Quick answers

Who received award R01NS129852?

R01NS129852 was awarded to University Of Oklahoma by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on September 1, 2023.

How much is award R01NS129852 worth?

$2,319,504 has been obligated on R01NS129852.

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