Determinants of sparse activity in neocortex
Active Project Grant Awarded Last action
- Award ID
- R01NS123711
- Recipient
-
Carnegie-Mellon University UEI U3NKNFLNQ613
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $7,384,554
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date 99% complete
- Place of performance
- Pittsburgh, PA 15213, USA
Award details come from USAspending.gov.
Description
- Abstract
- Synaptic plasticity in neocortical neurons is intimately tied to learning and memory. Decades of research in acute brain slices have characterized the patterns of spike timing required to evoke synaptic change in minute detail, but IT remains unknown whether these conditions occur and are sufficient to drive synaptic plasticity in the living brain. Indeed, in vivo recordings indicate that neocortical neurons live in an environment of profound inhibition that lowers overall firing rates and prevents plasticity. How then do cortical neurons escape this inhibition to encounter appropriate conditions for plasticity during learning? New evidence suggests that parvalbumin (PV) gabaergic neurons may play a dominant role in regulating cortical activity and controlling network rewiring, particularly at the early stages of learning. Using a multiwhisker stimulus coupled to a water reward, we have developed a paradigm for sensory association learning that drives rapid changes in excitatory synaptic strength in mouse barrel cortex. Importantly, our new data indicate that PV output to neocortical pyramidal neurons is markedly suppressed at the earliest stages of sensory training. Our experiments will integrate in vivo and acute brain slice recordings to test the hypothesis that PV neurons are a dominant regulator of sensory- evoked activity in mouse barrel cortex. We propose that reward-related acetylcholine release indirectly suppresses PV neural firing to depress PV output and increase sensory-evoked activity during learning. Our experiments will identify mechanisms for cortical disinhibition that facilitate experience-dependent synaptic plasticity in sensory cortex.
Transactions
| Action | Obligated | Date |
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| Amendment | $12,630 | |
| Amendment | $492,332 | |
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| Amendment | $455,632 | |
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| Amendment | $35,524 | |
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| Amendment | $456,763 | |
| Amendment | $456,763 | |
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| Amendment | $50,872 | |
| Amendment | $50,872 | |
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| Amendment | $457,861 | |
| Amendment | $457,861 | |
| Amendment | $457,861 | |
| Amendment | $457,861 | |
| Amendment | $457,861 | |
| Amendment | $543,117 | |
| Original award | $543,117 |
Show all 22
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Max-Delbrück-Centrum FÜR Molekulare Medizin In DER Helmholtz-Gemeinschaft | $107,417 | |
| Max-Delbrück-Centrum FÜR Molekulare Medizin In DER Helmholtz-Gemeinschaft | $104,194 |
Quick answers
Who received award R01NS123711?
R01NS123711 was awarded to Carnegie-Mellon University by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on February 15, 2022.
How much is award R01NS123711 worth?
$7,384,554 has been obligated on R01NS123711.
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