Characterizing persistent subclinical neurobehavioral effects of covid-19 in a diverse urban population

Active Project Grant Awarded Last action

Award ID
R01NS123445
Recipient
Awarding agency
Obligated
$6,757,596

Award facts

Completion date 91% complete
Place of performance
Bronx, NY 10461, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Excess cognitive dysfunction has been identified in older adult survivors of covid-19, compared to other respiratory infections. Sars-COV-2 may thus adversely impact the brain beyond what the cases of acute stroke, etc. Suggest. Unrecognized brain effects of sars-COV-2 infection may impact current brain functioning and presage future neurodegeneration and overt neurologic dysfunction. However, absent known baseline functioning, detection of subclinical effects will be confounded by normal variation between cases and controls. We will therefore leverage detailed pre-pandemic neurocognitive and imaging assessments to characterize subclinical effects on brain structure and function among a large cohort of younger patients who experienced mild or asymptomatic sars-COV-2 infection. We will identify 3 groups utilizing detailed serologic analysis and novel highly specific sars-COV-2 t-cell assays to allow confirmation of prior sars-COV-2 infection, even in the setting of covid-19 vaccination: (1) m ILD covid-19: 35 patients with laboratory confirmed covid-19 who were not hospitalized; (2) asymptomatic: 35 with laboratory evidence of sars-COV-2 infection, but no history of covid-19 symptoms; and (3) controls: 70 matched individuals without laboratory or clinical evidence of prior sars-COV-2 infection. All participants were healthy prior to covid-19, with no comorbid risk factors or brain imaging abnormality and normal neurocognitive performance. Against this robust quantitative baseline, we will assess change due to sars-COV-2 infection by repeating a suite of neurological assessments, including brain imaging and assessments of neurocognitive function, mood, anxiety, stress and social isolation due to the pandemic. In addition to their pre-pandemic baseline, we will assess participants (1) at entry into this proposed study, (2) 6 months after entry, (3) 18 months after entry and (3) three years after entry, to address the following: aim 1 brain tissue effects: characterize change of macro/microstructure and functional connectivity frompre- pandemic, among sars-COV-2 infected patients and non-infected controls, over three years. Aim 2 functional effects: assess change in neurocognitive function from pre-pandemic, among sars-COV-2 patients, and in non-infected controls, over three years, while accounting for mood, stress and social isolation. Aim 3 individual risk factors [exploratory]:explore whether individual characteristics, such as SEX, BMI, SES and race/ethnicity, modify the associations of sars-COV-2 infection with MRI and neurocognitive changes. Confirming neurological morbidity in mild sars-COV-2 will have key implications for screening, care and follow- up for brain dysfunction among those at risk. Theseproblems would otherwise go unrecognized, despite potential for long-term, yet-unrecognized morbidity. Our existing sample of previously healthy, young, ethnically diverse women and men from a high prevalence and high morbidity region, well-characterized prior to the covid-19 pandemic, uniquely positions US to characterize subclinical brain injury and dysfunction due to sars-COV-2.

Transactions

Action Obligated Date
Amendment $690,083
Amendment $622,584
Amendment $48,520
Amendment $48,520
Amendment $623,832
Amendment $623,832
Amendment $623,832
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $690,928
Amendment $690,928
Amendment $690,928
Amendment $690,928
Original award $712,681
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Subawards

Subrecipient Amount Awarded
The Trustees Of Columbia University In The City Of New York Characterizing persistent subclinical neurobehavioral effects of COVID-19 in a diverse urban population $195,202
Fordham University $47,648
The Trustees Of Columbia University In The City Of New York $175,683
Fordham University $42,883
The Trustees Of Columbia University In The City Of New York $209,096
The Trustees Of Columbia University In The City Of New York $136,167
Fordham University $47,648
Fordham University $47,648

Quick answers

Who received award R01NS123445?

R01NS123445 was awarded to Albert Einstein College Of Medicine by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on April 1, 2022.

How much is award R01NS123445 worth?

$6,757,596 has been obligated on R01NS123445.

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