Multipronged approach to diminish sympathetic hyperreflexia and ensuing cardiovascular and immune dysfunction after spinal cord injury
Active Project Grant Awarded Last action
- Award ID
- R01NS122371
- Recipient
-
Drexel University UEI XF3XM9642N96
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,696,883
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date 92% complete
- Funding
-
- $4,255,467.00 Federal
- $441,416.00 Non-federal
- Place of performance
- Philadelphia, PA 19129, USA
Award details come from USAspending.gov.
Description
- Abstract
- Spinal cord injury (SCI) is a devastating event sustained by as many as 1.3 million americans. While not often appreciated, cardiovascular disease and susceptibility to infection are leading causes of mortality and morbidity in individuals living with SCI. One major reason thought to underlie these issues is SCI-induced dysregulation of the sympathetic nervous system. In this proposal, we will use a clinically-relevant contusion rodent SCI model to test the hypothesis that intracellular sigma peptide (ISP) will promote sufficient sprouting of serotonergic axons onto neurons in the spinal sympathetic circuit below the SCI to normalize sympathetic activity after injury. Furthermore, we hypothesize that administering a combining ISP and inhibition of soluble tumor necrosis factor alpha (STNFA) with XPRO1595 - which target different root causes of sympathetic hyperreflexia after SCI (i.e., interrupted supraspinal input the spinal sympathetic circuit and STNFA-induced maladaptive plasticity of the spinal sympathetic circuit, respectively) - will have synergistic effects on improving cardiovascular and immune function after SCI.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $428,541 | $0 | |
| Amendment | $42,854 | $0 | |
| Amendment | $385,687 | $0 | |
| Amendment | $385,687 | $0 | |
| Amendment | $415,684 | $0 | |
| Amendment | $415,684 | $0 | |
| Amendment | $428,541 | $0 | |
| Amendment | $428,541 | $0 | |
| Amendment | $441,416 | $0 | |
| Amendment | $441,416 | $441,416 | |
| Original award | $441,416 | $0 |
Show all 11
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| George Washington University (The) | $22,240 | |
| Centre National De La Recherche Scientifique | $116,721 | |
| George Washington University (The) | $33,540 |
Quick answers
Who received award R01NS122371?
R01NS122371 was awarded to Drexel University by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on April 1, 2022.
How much is award R01NS122371 worth?
$4,696,883 has been obligated on R01NS122371: $4,255,467 in federal funding and $441,416 in non-federal funding.
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