Precise (perfusion imaging to identify posterior circulation candidates for thrombectomy)

Active Project Grant Awarded Last action

Award ID
R01NS121720
Recipient
Awarding agency
Obligated
$14,014,025

Award facts

Completion date 91% complete
Originally
Funding
  • $12,504,143.00 Federal
  • $1,509,882.00 Non-federal
Place of performance
Palo Alto, CA 94304, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Acute ischemic stroke is the leading cause of disability in the united states and the second-leading cause of death worldwide. AIS that involves a major cervical or cerebral artery is termed a large vessel occlusion, and recent landmark randomized studies found that endovascular thrombectomy is an effective treatment for ischemic stroke caused by large vessel occlusion of the internal carotid, middle, or anterior cerebral arteries (anterior circulation). However, up to 15% of large vessel occlusions occur in the vertebral or basilar arteries, and these posterior circulation stroke patients were largely excluded from modern endovascular thrombectomy trials. Clinical outcomes in patients with vertebral or basilar artery occlusions are often poor with severe disability or death occurring in 30-54% and 36-86% of patients, respectively. There are no prospective or randomized data designed to determine which imaging strategies should be used to guide thrombectomy treatment decisions in this understudied population. Precise (perfusion imaging to identify posterior circulation candidates for thrombectomy) is a prospective cohort study of patients with acute ischemic stroke due to occlusion of the vertebral or basilar artery within 24- hours of symptom onset. Patients will undergo CT or MRI cerebral perfusion imaging prior to endovascular thrombectomy treatment. The results of this study will determine if cerebral perfusion imaging can identify a subset of patients who are most likely to have a favorable outcome after thrombectomy treatment. Precise has the potential to improve the imaging evaluation of patients with acute ischemic stroke of the posterior circulation, to provide valuable prognostic information regarding thrombectomy efficacy in these patients, and to define sub-groups of patients who might benefit from future neuroprotective strategies.

Transactions

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Amendment $1,512,520 $0
Original award $1,512,520 $1,512,520
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Subawards

Subrecipient Amount Awarded
Emory University PRECISE (PeRfusion imaging to identify postErior CIrculation candidateS for thrombectomy) $27,000
The Charlotte-Mecklenburg Hospital Authority " Number of Performance Sites: 25 sites Projected Enrollment: 120 subjects Each site will be expected to enroll 1-2 patients per year throughout the duration of… $45,000
University Of Pittsburgh - Of The Commonwealth System Of Higher Education PRECISE (PeRfusion imaging to identify postErior CIrculation candidateS for thrombectomy) $14,000
Augusta University Research Institute, Inc. $21,000
The Trustees Of The University Of Pennsylvania "Each site will be expected to enroll 1-2 patients per year throughout the duration of the recruitment period. Enrollment is competitive, therefore, Stanford… $1,000
The Washington University $9,800
The Toledo Hospital Number of Performance Sites: 25 sites. Projected Enrollment: 120 subjects. Each site will be expected to enroll 1-2 patients per year throughout the duration of… $15,410
Regents Of The University Of Minnesota "Each site will be expected to enroll 1-2 patients per year throughout the duration of the recruitment period. Enrollment is competitive, therefore, Stanford… $17,975
Emory University PRECISE (PeRfusion imaging to identify postErior CIrculation candidateS for thrombectomy) $35,000
The Toledo Hospital Number of Performance Sites: 25 sites. Projected Enrollment: 120 subjects. Each site will be expected to enroll 1-2 patients per year throughout the duration of… $30,000
The Charlotte-Mecklenburg Hospital Authority " Number of Performance Sites: 25 sites Projected Enrollment: 120 subjects Each site will be expected to enroll 1-2 patients per year throughout the duration of… $30,000
Emory University PRECISE (PeRfusion imaging to identify postErior CIrculation candidateS for thrombectomy) $20,000
The Washington University "Each site will be expected to enroll 1-2 patients per year throughout the duration of the recruitment period. Enrollment is competitive, therefore, Stanford… $30,000
The Charlotte-Mecklenburg Hospital Authority " Number of Performance Sites: 25 sites Projected Enrollment: 120 subjects Each site will be expected to enroll 1-2 patients per year throughout the duration of… $15,000
The Ohio State University Number of Performance Sites: 25 sites. Projected Enrollment: 120 subjects. Each site will be expected to enroll 1-2 patients per year throughout the duration of… $11,070
The Ohio State University $5,000
University Of Pittsburgh - Of The Commonwealth System Of Higher Education "Each site will be expected to enroll 1-2 patients per year throughout the duration of the recruitment period. Enrollment is competitive, therefore, Stanford… $22,140
Augusta University Research Institute, Inc. The Augusta University Research Institute, inc., located in Augusta, Georgia, will serve as an enrolling site for PRECISE, and will be reimbursed for the… $10,000
The Trustees Of The University Of Pennsylvania "Number of Performance Sites: 25 sites Projected Enrollment: 120 subjects Each site will be expected to enroll 1-2 patients per year throughout the duration… $15,000
The Washington University "Each site will be expected to enroll 1-2 patients per year throughout the duration of the recruitment period. Enrollment is competitive, therefore, Stanford… $20,000
The Charlotte-Mecklenburg Hospital Authority " Number of Performance Sites: 25 sites Projected Enrollment: 120 subjects Each site will be expected to enroll 1-2 patients per year throughout the duration of… $25,000
University Of Southern California "Each site will be expected to enroll 1-2 patients per year throughout the duration of the recruitment period. Enrollment is competitive, therefore, Stanford… $15,000
Yale Univ "Version 1.0; August 6, 2021 1 STATEMENT OF WORK PRECISE Number of Performance Sites: 25 sites Projected Enrollment: 120 subjects Each site will be expected… $10,000
Regents Of The University Of Minnesota "Each site will be expected to enroll 1-2 patients per year throughout the duration of the recruitment period. Enrollment is competitive, therefore, Stanford… $15,000
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Quick answers

Who received award R01NS121720?

R01NS121720 was awarded to The Leland Stanford Junior University by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on August 1, 2021.

How much is award R01NS121720 worth?

$14,014,025 has been obligated on R01NS121720: $12,504,143 in federal funding and $1,509,882 in non-federal funding.

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