Project Grant R01NS115759

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $221,120 to the University of Texas Health Science Center at Houston (UTHealth) to investigate the potential of adult central nervous system endothelial cells to guide neural progenitor cell migration and enhance neurovascular communication. The research aims to boost...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $427,625 to the University of Washington to study whether electrical stimulation can enhance the efficacy of neural stem cell transplants for improving recovery from chronic spinal cord injury. The project aims to determine if electrical stimulation supports the survival...

The federal Project Grant award of $1,223,140 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to test a novel biopharmaceutical agent called Sanguinate for mitigating cerebral infarct growth in acute ischemic stroke. Sanguinate is designed to boost collateralization and deliver oxygen to ischemic tissue, with the goal of reducing infarct volume and...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $327,824 to the University of Washington to develop and optimize optogenetic spinal stimulation as a therapeutic intervention for severe spinal cord injuries. The key objectives are to: 1) Determine if increasing the frequency of optogenetic spinal stimulation...

This federal Project Grant award of $459,111 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate a novel pharmacological approach to mitigate neurovascular complications associated with diabetes in stroke patients. The primary awardee, the University of Tennessee Health Science Center, will explore the mechanisms by which a newly...

This federal Cooperative Agreement award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $1,038,313 to New York University School of Medicine to study the mechanisms by which paired vagus nerve stimulation (paired VNS) can enhance motor recovery in chronic stroke patients. The primary goals are to identify how paired VNS induces changes in motor, cognitive, and affective...

This $299,982 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program aims to evaluate the safety and efficacy of Unandup, LLC's novel magnetic infusion platform for accelerating alteplase-based thrombolysis to treat acute ischemic stroke. The proposed technology is designed to more rapidly convey and mix alteplase at the site of blood...

The University of California, Los Angeles (UCLA) received a $264,756 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant aims to examine cellular and neural responses to a novel hydrogel scaffold that promotes revascularization and axonal sprouting in a mouse model of ischemic stroke. Key objectives include longitudinally...

The University of Pittsburgh has been awarded a $428,400 federal Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to study the role of the astrocytic sodium bicarbonate transporter NBCE1 in regulating blood-brain barrier (BBB) integrity during ischemic stroke. The project aims to investigate whether pathological activation of NBCE1 in astrocyte endfeet contributes to...