This Project Grant award from the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $343,203 to Cyion Technologies LLC to develop a novel in vitro electrophysiology system for high-throughput measurement of intracellular action potential (IAP) in human-derived cardiomyocytes. The system leverages a 3D nanoelectrode array (NEA) technology to enable scalable recordings of IAP signals from many individual cardiomyocytes....
The National Institutes of Health (NIH) awarded a $1,417,500 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the University of California, Los Angeles (UCLA) to develop a novel "electrified cryo-EM" (ecryo-EM) technique that can capture the structural changes in neurons during action potentials. This 3-year project aims to: 1) demonstrate an ecryo-EM device that can trap metastable biological states under electrical stimulation, 2) elucidate the...
This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $254,456 to Neurobionics Inc. aims to develop a multifunctional neural probe that integrates electrical, optical, and chemical capabilities into a single implantable device for neuroscience research. The goal is to enable novel preclinical research into brain disorders and screening of neurological drug candidates by providing a versatile tool that can record neural activity,...
The National Institute of Neurological Disorders and Stroke (NINDS), through its Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program, awarded a $766,451 Project Grant (R44NS125892) to Axonova Medical LLC in April 2024. The grant is supporting the development of tissue engineered neuromuscular interfaces (TE-NMIs) using GalSafe neurons, an FDA-approved xenogeneic source. Specifically, the funding enables Axonova to establish CGMP-like...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, was awarded to Intelligent Imaging Innovations, Inc. (3i) to establish the feasibility of developing a commercial instrument for large-scale, all-optical electrophysiology. The $505,311 award, spanning January 1, 2025 to December 31, 2026, seeks to combine recent advancements in optical techniques, such as volumetric imaging of neural activity and...
This Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund the development of advanced tools for genetically targeted all-optical electrophysiology in behaving mice. Specifically, the $4,381,836 award to President and Fellows of Harvard College, doing business as Harvard University, will support efforts to co-develop two-photon excitable genetically encoded voltage indicators and a new type of two-photon voltage-imaging...
This $275,000 project grant from the National Science Foundation's Engineering Directorate (CFDA 47.041) will fund the development of novel electronic-photonic silicon carbide neural probes for recording and stimulating neural activity. The Georgia Tech Research Corporation will receive funding on behalf of collaborating researchers to design penetrating neural probes made entirely of silicon carbide, a robust material proven to withstand the corrosive brain environment long-term. The probes...
This NSF Engineering Program award of $605,320 to North Carolina State University (NC State) supports the development of a flexible, FMRI-compatible neural probe with multi-modal sensing and modulation capabilities. The novel probe is designed to advance understanding of neural circuit dynamics and enable closed-loop neuromodulation for treating neurological disorders. Key product elements include:
Flexible, multi-shank neural probe fabricated using polymeric materials to enable deep brain...
The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $3.6 million under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to Stanford University. The project grant will support development of a noninvasive, dynamically programmable in vivo light source for rapid brain-wide optogenetic screening. Specifically, the awardee aims to develop mechanoluminescent nanoparticles with distinct...
This $354,600 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative program (CFDA 93.372), will support the development of novel methodologies for simultaneous, distributed perturbation of multiple cortical regions in mice using patterned light. The goal is to enable researchers to infer how large-scale patterns of cortical activity...