Project Grant R01NS054122

This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to understand the molecular mechanisms by which collagen IV proteins regulate transforming growth factor beta (TGF-β) signaling in a mouse model of cerebral small vessel disease (CSVD). The 5-year, $770,502 award to the University of California, San Francisco aims...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), provides $776,503 to The General Hospital Corporation (Massachusetts General Hospital) to investigate the role of perivascular inflammation and vascular remodeling in cerebral small vessel diseases (CSVD), which can lead to intracerebral hemorrhage. The project will leverage autopsy cases and mouse...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders, provides $1,583,383 to the University of Connecticut Health Center (UCHC) for a research project titled "Regulation of FLT 1 Splicing by Fibronectin and Integrin Signaling During Aging." The research aims to elucidate the molecular mechanisms by which age-related vascular changes,...

This $559,893 Project Grant award from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of RSPO2 signaling through the LGR4 receptor in regulating arterial lymphangiogenesis, vascular smooth muscle cell phenotype, and atherosclerosis development. The project will be conducted by the University of Tennessee Health Science Center in Memphis, Tennessee over a 5-year period from January 2025 to...

The National Heart, Lung, and Blood Institute (NHLBI) awarded Stanford University a $171,720 project grant on June 23, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of COUP-TFII transcription factor in human vein development. The research will leverage a newly established stem cell differentiation protocol developed by collaborators at Stanford to generate highly pure venous endothelial cells (greater than 85% efficiency) from human pluripotent...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded Emory University a $430,375 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to study disease-associated mutations and ligand activation of the adhesion G protein-coupled receptor ADGRB2. The key objectives are to: Investigate newly identified patient mutations in the ADGRB2 gene that are associated with spastic paraparesis and other neurological symptoms,...

This $408,599 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of the TGF-beta/SMAD3 pathway in endothelial damage and cardiac remodeling caused by doxorubicin chemotherapy. The research aims to assess how doxorubicin-induced endothelial reprogramming via this pathway contributes to the development of cardiomyopathy, and whether suppressing SMAD3...

Trustees of Tufts College, doing business as Tufts University School of Medicine, received a $453,750 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding will support research to define the potential of gene therapy to correct motor disabilities associated with CTNNB1 syndrome, a rare genetic disorder characterized by intellectual...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, aims to elucidate the role of TGF-beta signaling in craniofacial fibrous dysplasia (CFD), a debilitating skeletal disease. With total funding of $306,600 awarded on September 24, 2024, the project will investigate the mechanisms driving TGF-beta signaling in response to constitutive activation of G-protein coupled receptor...

Teucer Diagnostics, Inc. received a $306,101 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective April 20, 2025, with completion targeted for March 31, 2026. The award supports development and validation of a novel RT-PCR (reverse transcription polymerase chain reaction)-based urinary biomarker assay that measures podocyte-specific markers—podocin and nephrin mRNA—to serve as an early...