Project Grant R01MH143880
- The National Institute of Mental Health awarded $452,386 to President and Fellows of Harvard College on September 1, 2026, to study the plasticity of synaptic cotransmission in the mouse lateral habenula under the Mental Health Research Grants program (CFDA 93.242). The research investigates how changes in the valence of learned associations induce synaptic plasticity in the lateral habenula—a brain structure implicated in mood disorders—and subsequently alter downstream dopamine signaling....
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $543,711 on August 20, 2026, under the Mental Health Research Grants program (CFDA 93.242, Assistance Listing R01MH145508) to investigate endocannabinoid-mediated inhibitory synaptic mechanisms of hippocampal plasticity using all-optical physiology. The research employs simultaneous patterned optogenetic stimulation and genetically targeted voltage imaging to track synaptic plasticity with millisecond and...
- The National Institute of Mental Health awarded $182,916 to Trustees of Tufts College, doing business as Tufts University School of Medicine, on October 17, 2025, under the Mental Health Research Grants program (CFDA 93.242) to conduct research evaluating cell type-specific mechanisms of glutamatergic synapse function and organization in interneurons. The research uses molecular biology, proteomic analysis, live cellular imaging, and electrophysiology to investigate how the protein BTBD11...
- The National Institute of Mental Health awarded Trustees of Boston University $449,625 on July 9, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct basic neuroscience research on behavioral functions of cotransmission in cost/benefit decision-making. The research examines how dopamine release in distinct striatal subregions supports different forms of learning—reward-based versus threat-based—and tests a specialized neural circuit linking the tail of the striatum,...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $128,000.00 to the Boston VA Research Institute, Inc. to investigate the spectral components of abnormal spontaneous gamma activity in schizophrenia and translational mouse models. The research aims to better understand the neural mechanisms underlying spontaneous gamma activity, which has been used as an index of excitation-inhibition...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded the University of Illinois $440,908 on July 27, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support a project investigating the roles of the prefrontal cortex and ventral hippocampus during adolescence in the maturation of social and cognitive behaviors. The research examines how changes in GABAergic inhibitory transmission in these limbic structures contribute to the refinement of higher cognitive functions and social...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology (MIT) $803,849 on June 3, 2026, as a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to conduct brain-wide analysis of input/output relationships in the reward system. MIT will use functional magnetic resonance imaging (fMRI) techniques to study integrated input/output relationships between brain regions involved in reward-related tasks. The research centers on a novel genetically...
- The National Institute of Mental Health awarded Massachusetts General Hospital $453,750 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, to develop a closed-loop system for assessing target network engagement using concurrent transcranial magnetic stimulation and functional MRI. The recipient is developing a flexible radiofrequency coil array (the RF Cap) that enables functional MRI acquisition simultaneously with transcranial magnetic stimulation in a...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $443,575 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how maternal immune activation alters dopamine circuit function and development. The project examines the structural and functional impact of in utero immune activation on the striosome-dendron bouquet, a striatal circuit that directly controls dopamine neurons in the substantia nigra pars compacta. Aim 1...
The National Institute of Mental Health awarded Massachusetts Eye and Ear Infirmary $666,010 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study co-transmission of GABA and glutamate in cortical circuits and the role of neuromodulatory inputs in adult cortical plasticity. The recipient will employ anatomical circuit tracing, whole-cell electrophysiology, and in vivo two-photon imaging in mouse cortex to investigate how cholinergic and serotonergic neuromodulatory inputs converge onto a unique cortical neuron subtype that co-expresses the vesicular glutamate transporter (VGLUT3) and the vesicular GABA transporter (VGAT). The project will characterize how these neurons release both glutamate and GABA onto specific postsynaptic targets and how this dual release influences cortical processing. The research addresses how neuromodulatory signals conveying information about behavioral state, vigilance, locomotion, and reward acquisition can reawaken adult cortical plasticity—a capability that typically declines after early life but could offer therapeutic pathways to enhance plasticity and treat mental disorders and neurological conditions. Performance occurs in Boston, MA. The project period runs from September 1, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $666.0k | 8/28/26 |