Project Grant R01MH139529
- Federal Grant Award Summary Oregon Health & Science University received a $150,104 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective December 30, 2025, with an ultimate completion date of June 30, 2028. The award funds basic neuroscience research investigating intracellular signaling mechanisms and dynamic control of synaptic responses in the basal ganglia, specifically examining how dendritic...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded Massachusetts General Hospital a Project Grant totaling $129,290 on August 22, 2025, under the Mental Health Research Grants program (CFDA 93.242). This research project, extending through July 31, 2027, focuses on mapping genotype to developmental course across an autism spectrum disorder (ASD) and schizophrenia (SCZ) gradient. The Principal Investigator will analyze phenotypic, genetic, and...
- Federal Grant Award Summary Massachusetts General Hospital's Research Management Division received a $824,728 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) on March 25, 2026, with an ultimate completion date of December 31, 2030. The award funds a multimodal neuroimaging research project investigating intracortical feedforward and feedback sensory processes in Autism Spectrum Disorder (ASD). The research employs...
- Federal Project Grant Award Summary The National Institute of Mental Health (NIMH) awarded The Broad Institute of MIT and Harvard a $475,388 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to conduct basic neuroscience research investigating the transcriptional and neuro-immune consequences of KDM5B loss in bipolar disorder (BD). The award, initiated June 16, 2025, and extending through June 15, 2027, supports a two-year research initiative examining how genetic...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded Massachusetts General Hospital a Project Grant totaling $183,118 on September 1, 2025, under the Mental Health Research Grants program (CFDA 93.242). Under the direction of Dr. Tubbs, this research initiative will deliver integrated genomic and electronic health record (EHR) analyses designed to advance precision psychiatry by addressing critical gaps in translating genetic findings to clinical practice. The...
- Federal Project Grant Award Summary Massachusetts General Hospital (MGH), through its Research Management Division, received a $412,500 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), effective September 1, 2025, through August 31, 2027. The award funds development of a copy number variant (CNV) discovery pipeline optimized for integrated genome-exome sequencing (BGE). The research addresses a critical gap in...
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a $534,191 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) on April 1, 2026, through the Mental Health Research Grants program (CFDA 93.242). The award supports research through December 31, 2030, focusing on the development of robust fine-mapping tools and novel statistical methods for genetic discovery in neuropsychiatric traits using deep phenotype data....
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded $394,200 to the Research Foundation For Mental Hygiene, Inc. (through its New York State Psychiatric Institute division) under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2025, for a five-year project period extending through July 31, 2030. This Project Grant funds a clinical research study examining the role of the anterior hippocampus in major depressive disorder (MDD) pathogenesis....
- Federal Grant Award Summary The National Institute of Mental Health (NIMH) awarded a Project Grant totaling $789,593 to the Research Foundation For Mental Hygiene, Inc. (operating as the New York State Psychiatric Institute) under the Mental Health Research Grants program (CFDA 93.242). The award, dated July 1, 2026, and scheduled for completion by March 31, 2031, funds basic neuroscience research investigating the circuit mechanisms underlying early-life adversity (ELA)-induced reward deficits....
- Federal Project Grant Award Summary Weill Medical College of Cornell University received an $800,667 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded March 10, 2026, with completion targeted for December 31, 2030. The grant funds basic biomedical research investigating transcriptional control mechanisms related to autism-associated histone H3K9 methylation regulators during human neurogenesis. The research...
Mainehealth, a Portland, Maine-based nonprofit healthcare system, received a $466,738 Project Grant from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), awarded June 24, 2026, with completion scheduled for March 31, 2031. The award supports research investigating allelic DIO3 (deiodinase 3) control of brain development and behavior, specifically examining how alterations in thyroid hormone states during neurodevelopment—driven by epigenetic phenomena, maternal thyroid disease, or environmental endocrine disruptors—contribute to the etiology of neurodevelopmental and psychiatric disorders that display marked sex bias. The research employs transgenic mouse models with altered DIO3 expression and developmental thyroid hormone exposure to determine the neurological impact of aberrant DIO3 allelic expression and evaluate the role of DIO3 deficiency in brain sexual differentiation and associated behavioral phenotypes. The project addresses a critical gap in understanding genetic and environmental contributions to conditions including autism and schizophrenia, where high heritability (approximately 80%) contrasts sharply with the limited percentage of cases explained by identified genetic factors. Deliverables include neurobiological characterization of gene expression programs in the developing brain, brain morphology assessment, behavioral analysis relevant to neurodevelopmental conditions, and identification of mechanisms linking altered thyroid hormone signaling to psychiatric disease manifestation across sexes.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $466.7k | 6/30/26 |