Project Grant R01MH139463
- The National Institute of Mental Health awarded the University of Alabama at Birmingham $409,750 on March 15, 2026, under the Mental Health Research Grants program (CFDA 93.242) to determine the role of localized dopamine signals in learning. The research uses two-photon microscopy and genetically encoded sensors to simultaneously track dopamine release and neuronal activity in real-time as mice perform a neuroprosthetic control task. The work investigates whether dopamine shapes learning at the...
- The National Institute of Mental Health awarded the University of Texas at Austin $629,098 under the Mental Health Research Grants program (CFDA 93.242) on June 1, 2026, to develop advanced optical and sono-chemogenetic systems for probing dopamine dynamics in the non-human primate brain. The recipient will establish and characterize the dLight sensor, a genetically encoded fluorescent dopamine indicator, in the macaque animal model to enable cell-type-specific recording of dopamine circuitry....
- The National Institute of Mental Health awarded President and Fellows of Harvard College $674,028 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the determinants and function of tonic dopamine signaling in the striatum. The research develops and applies real-time measurement methods to distinguish tonic dopamine (slowly changing baseline levels) from phasic dopamine (rapid transient signals) in mice across multiple behavioral contexts. The project...
- The National Institute of Mental Health awarded The Research Foundation for The State University of New York $437,125 on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a preliminary positron emission tomography study quantifying the mechanism of transcranial magnetic stimulation in depression. The recipient, operating as Stony Brook University, will investigate the relationship between repetitive transcranial magnetic stimulation (rTMS)—an FDA-approved...
- The National Institute of Mental Health awarded the University of Pittsburgh $728,751 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neural mechanisms by which antidepressant placebo effects modulate mood in patients with major depressive disorder. The research dissects expectancy-driven dynamics between the salience network and default mode network using theta burst stimulation in a 200-patient, randomized, factorial design. The study...
- This $576,337 National Institute of Mental Health project grant funds research at Stanford University to evaluate a biomarker-guided intervention approach for anhedonia in treatment-resistant depression. The grant supports a clinical trial targeting D3 receptor agonism with pramipexole to determine its effects on ventral striatum brain activation as measured by functional neuroimaging. The study aims to enroll treatment-resistant depression patients with prominent anhedonia to evaluate whether...
- The National Institute of Mental Health awarded $1,415,720 to Deliberate Solutions Inc. on August 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to advance AI-CLINICAL OUTCOME ASSESSMENT (AI-COA) for Depression toward regulatory qualification and commercial readiness as a drug development tool. The project funds technical development and clinical validation of AI-COA, a multimodal artificial intelligence tool designed to provide objective, standardized assessment of...
- The National Institute of Mental Health awarded Northwestern University $400,000 on May 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate seizure networks in electroconvulsive therapy outcomes. The research will characterize how seizure activity progresses through brain regions and networks during ECT in treatment-refractory depression, with focus on understudied seizure-network nodes including piriform cortex, substantia nigra, and cerebellar nuclei that...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $192,192 on April 15, 2026, to develop an artificial intelligence foundation model for functional neuroimaging that predicts treatment response, stratifies patients, and identifies biotypes in major depressive disorder under CFDA 93.242 (Mental Health Research Grants). The award funds three specific aims. Aim 1 applies pooled functional MRI data from individuals with major depressive disorder to fine-tune a...
- The National Institute of Mental Health awarded Northwestern University $781,358 on April 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to determine the mechanisms and therapeutic potential of novel cholinergic antipsychotics. The research investigates how cholinergic receptor agonists such as xanomeline and the M4 receptor selective modulator VU0467154 work as antipsychotics and whether they may be effective for patients unresponsive to traditional dopamine D2...
The National Institute of Mental Health awarded Northwestern University $714,760 on July 21, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct a neuroimaging ancillary study investigating dopaminergic mechanisms of depression and antidepressant response in persons with HIV. The study will enroll 48 participants from a larger clinical trial comparing pramipexole (a dopamine agonist) against escitalopram (an SSRI) for antidepressant efficacy in major depressive disorder in HIV-positive individuals. Participants will undergo FDA-approved SPECT/CT imaging to measure striatal dopamine transporter levels in the caudate and putamen, supplemented by multiparametric MRI to assess the striatum, midbrain regions (substantia nigra and ventral tegmentum), and specific neural networks (salience, somatomotor, default mode, and central/frontal executive). The research will employ Research Domain Criteria to evaluate depression symptom profiles. The study aims to test whether striatal dopaminergic levels are reduced prior to treatment and correlate with symptom severity and brain alterations, and whether pramipexole reverses dopamine transmission deficits more effectively than escitalopram over 24 weeks of treatment, with changes in dopamine transporter availability and brain imaging measures correlating to symptom remission. Work is performed in Illinois. The project period runs through June 30, 2031. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $714.8k | 7/23/26 |