This Project Grant award from the National Institute of Mental Health (NIMH), under CFDA Program 93.242 Mental Health Research Grants, will support the development of novel tools to enable researchers to better understand the link between brain structure and function. The $323,978 award to the Child Mind Institute Inc., a non-profit research organization based in New York, will fund three key objectives: 1) extending a brain microstructure reconstruction tool called BrainBuilder to create...
This Cooperative Agreement award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is funding the creation of comprehensive three-dimensional (3D) brain cell atlases for both humans and non-human primates. The $11,731,574 award to the Massachusetts Institute of Technology (MIT) will enable the seamless integration of multimodal data, including functional, structural, diffusion MRI, and multiscale 3D proteomic/transcriptomic...
The National Institute of Mental Health (NIMH) awarded a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Weill Medical College of Cornell University for $582,953. The project, titled "The KrackenCoder: A Multi-Modal Connectome Fusion Tool for Brain-Behavior Mapping," aims to create and validate computational tools that integrate and estimate multi-modal brain connectivity data across many individuals, with and without diagnoses, in a behaviorally relevant...
The National Institute of Mental Health (NIMH) awarded a $314,113 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Physical Sciences Inc. (PSI) of Andover, MA. The grant will fund the development and demonstration of a high-speed, multicolor confocal fluorescence imager to simultaneously capture multi-wavelength signals and display them as separated or merged multicolor images and 3-D stacks. This technology innovation will enable mapping of complex neuronal network...
This Project Grant award of $517,546, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to optimize, benchmark, and validate a novel multimodal microelectrode array (MEA) probe that integrates fast-scan cyclic voltammetry (FSCV) for sub-second neuromodulator sensing with parallel electrical recording. The research team, led by investigators from Dartmouth College, aims to develop this integrated MEA platform...
The National Institute of Mental Health awarded a three-year Project Grant totaling $3,618,976 to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) to develop in situ single-cell multi-omic and morphological profiling methods for mammalian brains. Specifically, the university will work to design photonic-indexing sequencing strategies to spatially barcode tissue with single-cell resolution, integrating techniques such as PI-ATAC-seq and...
This federal Project Grant award of $1,920,113, awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports a research project titled "Narrowing the Mechanistic Gap for Anterior Prefrontal Cortex Function". The project aims to conduct a deep dive on the anatomy and function of the anterior lateral prefrontal cortex (ALPFC) region of the brain, which has been implicated in various mental health disorders such as...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $457,026 to Magnify Biosciences Inc. from August 1, 2024 to July 31, 2026. The goal of this project is to develop a prototype of the "Multiplex Magnify" sample preparation kits as a universal tool for synapse typing and advanced 3D brain imaging in neuroscience research. The key products and services to be delivered include:...
The National Institute of Mental Health (NIMH) awarded a $252,125 Project Grant under the Mental Health Research Grants (CFDA 93.242) program to The Trustees of Columbia University in the City of New York to conduct research on the neural mechanisms underlying context-dependent decision-making. The research aims to use functional magnetic resonance imaging (fMRI) in mice to identify brain regions involved in maintaining contextual information to guide decisions, and then employ optogenetics...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....