Family psychoeducation for adults with psychotic disorders in tanzania (kupaa trial)

Active Project Grant Awarded Last action

Award ID
R01MH136145
Recipient
Awarding agency
Obligated
$3,669,793

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 49% complete
Place of performance
Chapel Hill, NC 27599, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Family psychoeducation for adults living with psychotic disorders in tanzania (kupaa trial) psychotic disorders such as schizophrenia contribute to the global burden of disease in low- and middle- income countries (lmics) yet mental health services have been severely neglected. Family psychoeducation is an evidence-based practice from high-income countries that could have a significant impact in settings such as africa and other regions worldwide where resources are limited and family involvement in treatment is fundamental. In response to PAR-21-130, this R01 will evaluate the impact of a culturally tailored version of family psychoeducation called kupaa (meaning "to soar" in swahili) that is group-based and family-involved in a low-income country context. The kupaa intervention was recently pilot tested with adults living schizophrenia-spectrum disorders and their families in tanzania. The proposed hybrid effectiveness- implementation clinical trial would individually randomize patient-caregiver pairs to either the group-based intervention or the standard of care across 14 health facilities in four regions of tanzania. The overall objective is to improve recovery outcomes for individuals with schizophrenia-spectrum disorders. Aim #1: determine the effectiveness of kupaa VS. Standard of care for an outpatient population (n=432) by reducing disability and improving quality of life (primary outcomes); and reducing hospitalizations and reducing perceived family burden for caregivers (secondary outcomes) among matched patient-caregiver dyads. Aim #2: examine the mechanisms of change underlying kupaa as a group-based, family-involved intervention. Aim #3: evaluate implementation outcomes guided by the consolidated framework for implementation research (cfir) via mixed methods (n=122 semi-structured interviews, observational data, cost data). This project is a collaboration between the university of north carolina at chapel hill, duke university and four tanzanian institutions: muhimbili university of health and allied sciences in DAR ES salaam, mbeya zonal referral hospital in mbeya, mirembe national mental health hospital in dodoma, and kilimanjaro christian medical university college in moshi. This proposal aligns with the nimh cross-cutting global mental health theme and will contribute to nimh's goal of advancing mental health services to strengthen public health by providing insights on an adapted evidence-based practice designed for lower-resource settings that could also inform domestic implementation strategies for scaling family psychoeducation in the U.S.

Transactions

Action Obligated Date
Amendment $0
Amendment $91,076
Amendment $91,076
Amendment $94,792
Amendment $94,792
Amendment $91,703
Amendment $91,703
Amendment $99,946
Amendment $99,946
Amendment $386,508
Amendment $386,508
Amendment $682,139
Amendment $729,802
Original award $729,802
Show all 14

Subawards

Subrecipient Amount Awarded
Mbeya Zonal Referral Hospital Mbeya Zonal Referral Hospital will be responsible for providing technical assistance to the project and leading the intervention implementation and local data… $236,660
Kilimanjaro Christian Medical College Kilimanjaro Christian Medical College team will be responsible for providing technical assistance to the project and leading the intervention implementation and… $242,709
Mirembe National Mental Health Hospital Mirembe National Mental Health Hospital will be responsible for providing technical assistance to the project and leading the intervention implementation and… $239,750
Duke University Duke will be responsible for providing technical assistance to the project related to study design, data collection, data analysis related to the randomized… $133,048
Muhimbili University Of Health And Allied Sciences Muhimbili will be responsible for providing technical assistance to the project and leading the intervention implementation and local data collection. $267,325

Quick answers

Who received award R01MH136145?

R01MH136145 was awarded to University Of North Carolina At Chapel Hill by National Institute of Mental Health (National Institutes of Health) on June 1, 2024.

How much is award R01MH136145 worth?

$3,669,793 has been obligated on R01MH136145.

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