The National Institute of Mental Health (NIMH) awarded a Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the Research Foundation For Mental Hygiene, Inc. (RFMH) in the amount of $459,613. The award, titled "Modulating Endogenous Opiate Signaling to Reverse Stress-Induced Deficits in Reward Processing," aims to investigate the use of molecules called DENKIs to inhibit the degradation of endogenous enkephalins and reverse deficits in reward processing...
This $509,279 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) supports research into the role of 5-HT2A receptor signaling in treating stimulant use disorder. The principal investigator and prime awardee, The Medical College of Wisconsin, Inc., will conduct studies examining how 5-HT2A receptor agonists, including psychedelic drugs, can suppress the reinforcing effects of methamphetamine, promote neuroplasticity, and...
The National Institute of Mental Health (NIMH) awarded a $517,546 Project Grant (CFDA 93.242 Mental Health Research Grants) to Trustees of Dartmouth College to develop a novel multimodal microelectrode array (MEA) probe with integrated fast-scan cyclic voltammetry (FSCV) for sub-second neuromodulator sensing and parallel electrophysiological recording. This 5-year award, running from December 2024 to October 2029, aims to optimize, benchmark, and validate the EPHYS-FSCV MEA platform for...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $203,390 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to measure the interactions between adenosine 2A receptors (A2AR) and dopamine D2 receptors (D2R) in the striatum using non-invasive PET neuroimaging.
The key objectives are to: 1) Demonstrate the antagonistic interactions between A2AR and D2R...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, provides $826,675 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research aimed at improving cognitive deficits in psychotic disorders. The key objectives are to:
Derive a quantitative structure-activity relationship to optimize the enhancement of the ARC protein, which plays a key role in...
The National Institute of Mental Health (NIMH) awarded a $242,310 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to The Johns Hopkins University. The award supports research on "Head Scanning Behavior and Reward Interactions in Potentiation of Place Fields" from September 2024 to March 2026. The project aims to use in vivo electrophysiology recordings in the hippocampus to examine how rewards evoke head scanning behavior and influence place field...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a $252,125 multiscale neuroimaging study on the neural mechanisms underlying context-dependent decision-making in mice. The principal investigator, a physician-scientist, will leverage fMRI and optogenetics to identify brain regions that maintain contextual information and how their activity shapes decision-making processes. The findings aim...
This federal Project Grant award in the amount of $131,990 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will investigate the effects of psychedelic 5-HT2A agonist drugs on reversing aberrant reward-seeking behavior in an animal model of early-life adversity. The research, to be conducted by the University of California, Irvine, aims to replicate and extend previous findings showing that a single dose of the psychedelic...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $563,934 to Tufts University School of Medicine to conduct research studies on G-protein coupled receptors activated by neuroactive steroids. The key objectives are to: 1) evaluate the effects of neuroactive steroids on intracellular signaling via distinct membrane progesterone receptor (MPR) subtypes; 2) assess the role of the MPRD...
This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 (Mental Health Research Grants) provides $638,872 to The Feinstein Institutes for Medical Research to elucidate the modulation of the reward network by deep brain stimulation (DBS) of the medial forebrain bundle as a treatment for treatment-resistant depression.
The key products and services to be delivered include:
Characterizing the temporality of reward network changes induced by medial...
This Project Grant award from the National Institute of Mental Health (NIMH) under CFDA 93.242 Mental Health Research Grants provides $766,842 to The Mclean Hospital Corporation in Belmont, MA from April 1, 2025 through March 31, 2030. The goal of this project is to employ a reverse-translated touchscreen reward learning task in rats to identify the neurochemical drivers of MDMA's prohedonic (pleasure-enhancing) therapeutic efficacy. The research aims to associate electrophysiological biomarkers and task metrics with MDMA treatment, evaluate the roles of MDMA's enantiomers and metabolites, and examine how the kappa-opioid receptor system regulates the behavioral and electrophysiological processes of enhanced reward learning. The findings are expected to inform the development of novel medications to improve upon MDMA's therapeutic profile for psychiatric conditions involving anhedonia.