Integrating developmental and genomic approaches to identify early trajectories of eating and internalizing disorder symptoms

Active Project Grant Awarded Last action

Award ID
R01MH134039
Recipient
Awarding agency
Obligated
$2,507,926

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 64% complete
Place of performance
Chapel Hill, NC 27599, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Eating disorders (ED) and non-eating disorders internalizing-spectrum disorders (noned-INT; e.g., major depressive disorder, generalized anxiety disorder, social phobia, obsessive-compulsive disorder, posttraumatic stress disorder) have major public health importance due to their prevalence and significant personal and societal costs. These disorders often onset during adolescence and CO-occur. Despite years of psychiatric research, detection and prevention strategies for ED and noned-INT are not optimal. Little is understood about the developmental course of ED and noned-INT symptoms, particularly their CO-development, and the degree to which shared VS. Unique genetic and phenotypic factors underlie ED and noned-INT risk. In this study, we will elucidate the taxonomy of ED and noned-INT symptoms: clarifying their joint (i.e., as an overarching internalizing dimension) and specific developmental course and identifying genetic and environmental predictors. We will leverage the rich genomic and phenotypic data from two large and well-characterized cohorts - the adolescent brain and cognitive development (ABCD) and the avon longitudinal study of parents and children (ALSPAC) cohorts. We will deliver developmental models of ED and noned-INT symptom course, explicate their joint and specific risk (genetic and environmental), and assess differences in models across samples and race/ethnicities. We propose three specific aims: first, using ABCD and ALSPAC data, we will empirically identify trajectories of ED and noned-INT symptoms across development for each cohort and assess stability of the models across SEX, race, and ethnicity. Second, using multi-trait genomic methods, we identify unique and common genetic risk across ED and noned-INT phenotypes. Finally, we will determine genetic and phenotypic longitudinal predictors of ED and noned-INT trajectories in each cohort and elucidate the stability and robustness of a predictive model based on both genetic and early-life risk indicators. In the short-term, our results will lend clarity to the taxonomy of ED and noned-INT. In the long-term, improved understanding of developmental pathways will aid early intervention and identification of high-risk youth.

Transactions

Action Obligated Date
Amendment $160,275
Amendment $370,027
Amendment $432,501
Amendment $587,548
Original award $587,548

Subawards

Subrecipient Amount Awarded
Region Hovedstaden The Research Team will investigate developmental overlap between eating disorders and internalizing disorders and investigate its genetic basis, provide data… $336,635
University Of Wisconsin System The Department of Psychiatry will conduct literature review, preparation of phenotypic data for analysis, maintain reproducible repositories for sharing… $154,159
Research Triangle Institute Research Triangle Institute will be responsible for conducting data analysis associated with the second aim of the proposal, which involves conducting complex… $58,420

Quick answers

Who received award R01MH134039?

R01MH134039 was awarded to University Of North Carolina At Chapel Hill by National Institute of Mental Health (National Institutes of Health) on May 1, 2024.

How much is award R01MH134039 worth?

$2,507,926 has been obligated on R01MH134039.

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