2/3 akili: phenotypic and genetic characterization of adhd in kenya and south africa
Active Project Grant Awarded Last action
- Award ID
- R01MH132965
- Recipient
-
The Aga Khan University- Kenya UEI VJ84MM7PBNM3
- Awarding agency
-
National Institute of Mental Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $3,154,641
Award facts
- Assistance listing
- 93.242 Mental Health Research Grants
- Completion date 67% complete
- Place of performance
- Kenya
Award details come from USAspending.gov.
Description
- Abstract
- Adhd is a common neurodevelopmental disorder that includes attention difficulty, impulsivity, and hyperactivity. The diagnosis is associated with many challenges to educational, occupational, and health outcomes, particularly when untreated. Genetic studies of adhd have the potential to clarify the disorder's biological underpinnings, its heterogeneity, and its relationship to other neuropsychiatric diagnoses. However, genetic research into adhd lags in terms of: (1) sample size, (2) ancestral diversity, and (3) consideration of phenotypic heterogeneity. Akili is designed to address all three of these critical gaps. Akili (the swahili term for "mind") will enroll 6,000 children in kenya and south africa - 4,000 with a confirmed diagnosis of adhd and 2,000 age- and ancestry-matched controls. All participants will complete a detailed behavioral, cognitive, and medical phenotyping battery, and provide a DNA sample. We will genetically characterize all 6,000 participants using exome sequencing and genome-wide genotyping, and make all akili data and materials publicly available through the nimh. Akili data will nearly double the number of adhd cases available for exome sequencing analysis and provide a 20% addition to the current PGC-adhd gwas activity. IT will be by far the largest contributor of diverse ancestry data to either analysis. Akili will generate a research resource of international value, and provide the first large-scale characterization of adhd in the african context.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $498,881 | |
| Amendment | $514,809 | |
| Amendment | $529,681 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $537,090 | |
| Amendment | $537,090 | |
| Original award | $537,090 |
Quick answers
Who received award R01MH132965?
R01MH132965 was awarded to The Aga Khan University- Kenya by National Institute of Mental Health (National Institutes of Health) on August 1, 2023.
How much is award R01MH132965 worth?
$3,154,641 has been obligated on R01MH132965.
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