Reward, salience and value processing in youths at risk for psychosis: the rsvp study

Active Project Grant Awarded Last action

Award ID
R01MH131566
Recipient
Awarding agency
Obligated
$4,851,573

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 56% complete
Place of performance
Baltimore, MD 21201, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Schizophrenia and its clinical risk states are characterized by both positive and negative symptoms. Positive symptoms in schizophrenia comprise hallucinations and delusions; among teens and young adults at clinical high-risk (CHR) for psychosis, these are subthreshold in nature (e.g., perceptual disturbances and unusual thoughts). Negative symptoms in schizophrenia and CHR include anhedonia (the reduced experience or expectation of pleasure) and avolition (a severe reduction in motivated, goal-directed behavior). Prior work in schizophrenia suggests that both types of symptoms may result from impairment in salience processing, which is the appropriate evaluation of the importance and relevance of diverse experiences for normative learning and decision-making. Adaptive salience is the appropriate response to good or positive experiences; its blunting has been linked to both anhedonia and avolition. Positive symptoms in schizophrenia have been associated with aberrant salience, which is the inappropriate assignment of importance to neutral events. In this proposal, we will study salience processing and symptoms in CHR individuals, who have evolving pathophysiology and minimal antipsychotic exposure. We will, for the first time, study both adaptive and aberrant salience together in a CHR cohort sufficiently large (N = 96) to allow simultaneous examination of both negative and positive symptoms, who will be followed prospectively for clinical and functional outcome. We will use fmri and computational modeling of reinforcement learning and decision-making to capture quantitative behavioral and neural correlates of: (aim 1) blunted adaptive salience (and associations with negative symptoms); and (aim 2) heightened aberrant salience (and associations with positive symptoms). In longitudinal study (aim 3), we will determine the extent to which these two types of salience processing predict future and/or track change in symptom severity and functional outcome. Exploratory analyses will use all behavioral, imaging, and clinical data to determine if some salience subconstructs may contribute to both positive and negative symptoms. This proposal is significant for several reasons. There are, as yet, no robustly effective treatments for the CHR syndrome, which has significant current morbidity related to its positive and negative symptoms (in addition to cognitive deficits). Also, the CHR syndrome offers an opportune window for preventive intervention related to worsening symptoms and function and has the added advantage of minimal confounding by illness chronicity and antipsychotic medication use. Finally, if we find that the neural and behavioral mechanisms involved in salience processing are associated with negative and positive symptoms, this offers a promising novel target for treatment of both types of symptoms across the schizophrenia spectrum.

Transactions

Action Obligated Date
Amendment $790,425
Amendment $121,143
Amendment $121,143
Amendment $686,479
Amendment $686,479
Amendment $81,524
Amendment $81,524
Amendment $760,952
Amendment $760,952
Original award $760,952

Subawards

Subrecipient Amount Awarded
The Trustees Of The University Of Pennsylvania Reward, Salience and Value Processing in Youths at Risk for Psychosis: The RSVP Study $53,044
Icahn School Of Medicine At Mount Sinai $50,874
The Trustees Of The University Of Pennsylvania $300,582
Icahn School Of Medicine At Mount Sinai $32,133
The Trustees Of The University Of Pennsylvania $332,800
Icahn School Of Medicine At Mount Sinai $289,195

Quick answers

Who received award R01MH131566?

R01MH131566 was awarded to University Of Maryland, Baltimore by National Institute of Mental Health (National Institutes of Health) on March 1, 2024.

How much is award R01MH131566 worth?

$4,851,573 has been obligated on R01MH131566.

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