Efficacy of a differentiated care intervention for adolescents transitioning to adult HIV care in peru

Active Project Grant Awarded Last action

Award ID
R01MH131414
Recipient
Awarding agency
Obligated
$5,724,707

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 86% complete
Place of performance
Boston, MA 02115, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The transition from pediatric to adult care is an exceptionally precarious time in adolescent HIV care. Yet, little is known about which interventions might be most effective in supporting adolescents through this period. We will build on our well-established community-health platform and existing intervention research with adolescents living in lima, peru, to provide critical data on the effectiveness, cost, and implementation of a promising community-based differentiated care intervention that supports adolescents as they transition to adult HIV care. Our recent pilot study among a diverse group of 30 adolescents in peru, the first of its kind in latin america, demonstrated broadscale acceptability and convincing evidence of effectiveness with regard to outcomes of adherence, social support, self-efficacy and transition readiness. The intervention consists of stabilization of acute needs (e.g., housing instability or homelessness); health systems navigation to overcome administrative barriers to care (i.e., insurance changes, health center transfers); accompaniment to appointments in the adult clinic; social support groups; education and skills-building sessions; and mental health screening and referrals. The intensity of support and duration of the intervention (6 months or 12 months) will be differentiated based on patient-level factors such as adherence, viral load suppression, presence of familial support, and transition readiness. We will conduct a two-arm randomized clinical trial to determine the short- and long-term (i.e., post-intervention) efficacy of the intervention with regard to retention with viral load suppression as well as other indicators of well- being. We will compare the cumulative incidence of unsuccessful transition at 12- and 24-months, and stratify findings by the differentiated care pathway (i.e., the intensity of the intervention received). We will estimate the cost and cost-effectiveness of the study intervention in terms of cost per additional successful transition achieved. And, we will provide data on implementation considerations essential for uptake, sustainability, and successful adoption by the public sector. These include the reach of the intervention and the effectiveness and relative importance of each intervention component over the short and long-term. In pursuing these aims we will address a critical disparity of information with regard to interventions for adolescents living with HIV in the latin american context.

Transactions

Action Obligated Date
Amendment $206,856
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Amendment $802,879
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Original award $802,879
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Subawards

Subrecipient Amount Awarded
Socios En Salud Sucursal Peru Dr. Renato Errea is a Peruvian Medical Doctor and Chief of the Socios En Salud HIV Program. He will serve as the Sub PI / Project Director for this… $36,659
Brigham & Womens Hospital Inc. Dr. Sonya Shin, MD, MPH, will serve as a Co-Investigator and senior advisor on the study. Dr. Shin is an Associate Professor of Medicine and infectious… $61,598
Socios En Salud Sucursal Peru Socios En Salud is the local site in Lima, Perú on the study. Socios en Salud is responsible for implementing all field activities in Lima and will oversee… $484,880
Socios En Salud Sucursal Peru $0
University Of South Florida Jerome Galea, PhD, MSW, Co-Investigator, will provide support in the area of qualitative methods, implementation science, and mental health. He will provide… -$19,200
Brigham & Womens Hospital Inc. Dr. Sonya Shin, MD, MPH, will serve as a Co-Investigator and senior advisor on the study. Dr. Shin is an Associate Professor of Medicine and infectious… $39,461
Socios En Salud Sucursal Peru Socios En Salud is the local site in Lima, Perú on the study. Socios en Salud is responsible for implementing all field activities in Lima and will oversee… $320,270

Quick answers

Who received award R01MH131414?

R01MH131414 was awarded to President And Fellows Of Harvard College by National Institute of Mental Health (National Institutes of Health) on September 15, 2022.

How much is award R01MH131414 worth?

$5,724,707 has been obligated on R01MH131414.

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