Genomics of autism in latinx ancestries

Active Project Grant Awarded Last action

Award ID
R01MH128813
Recipient
Awarding agency
Obligated
$6,731,952

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 95% complete
Place of performance
New York, NY 10029, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The genetic architecture of autism spectrum disorder (ASD) is complex and ongoing efforts to decipher IT have focused on both common and rare genetic variants. Our investigative team has added significantly to current understanding of ASD genetic risk and to the functional impact of identified genes. Despite our large-scale genetic analyses, there remains a number of unanswered questions, one of which is whether its genetic architecture differs across ancestral populations. Notably, there has been no systematic effort to investigate this in hispanic and latina/latino populations, the largest minority population in the united states (~60 million, 18% of the total population), and growing rapidly. Inclusion of under-represented populations in genetic studies is important both for scientific reasons and for parity. This proposal therefore encapsulates 2 nimh priorities: we will investigate genetic risk for ASD in people of hispanic/latinx ancestry. To further our understanding of ASD in hispanic/latinx populations, we propose to: 1) recruit, phenotype and sample at least 1,600 additional hispanic/latinx ASD trios, thereby expanding our existing sample set of well-characterized hispanic/latinx ASD samples; 2) genotype and sequence all samples in the cohort and combine results with the autism sequencing consortium and the psychiatric genomics consortium, large-scale efforts on rare and common genetic variation, respectively; 3) analyze common genetic variation in the cohort using cross-ancestry genome-wide association studies (GWAS), develop ancestry-informed polygenic risk scores, and contribute to fine-mapping and colocalization of top GWAS findings; and, 4) carry out genetic association studies for rare genetic variants in the cohort, taking special care to account for ancestry, especially for rare inherited variation. At the successful conclusion of the proposed studies, we will have four important results: a deeper understanding of how rare and common variation contribute to risk for ASD across ancestries; enhanced fine-mapping of ASD GWAS loci; better, more portable PRS for diverse ancestries; and a larger number of known ASD risk genes. In addition, we will have contributed to improving methods for integrating samples of diverse ancestry in genomic studies and will have enhanced recruitment of under-represented populations in such studies.

Transactions

Action Obligated Date
Amendment Genomics of autism in latino ancestries - the genetic architecture of autism spectrum disorder (ASD) is complex and ongoing efforts to decipher IT have… $762,896
Amendment $608,945
Amendment $75,205
Amendment $75,205
Amendment $676,858
Amendment $676,858
Amendment $676,858
Amendment $782,014
Amendment $782,014
Amendment $71,979
Amendment $71,979
Amendment $71,979
Amendment $699,581
Original award $699,581
Show all 14

Subawards

Subrecipient Amount Awarded
The Children's Hospital Corporation Dr. Pilar Trelles, subcontract PI at Boston Children's Hospital will be responsible for sample ascertainment, capacity development and phenotypic… $99,320
The Broad Institute, Inc. Overview and Aims Sample Initiation and Sequencingâ€â€�We will sequence 4556 APN-GALA samples on the Blended Genome Exome (BGE) product, which provides an… $389,679
Emma Pendleton Bradley Hospital Dr. Pilar Trelles, subcontract PI at Bradley Hospital will be responsible for sample ascertainment, capacity development and phenotypic harmonization across our… $0
Universidad De LOS Andes In Medellin, we will work with the Fundacion Integrar, an institution that provides support to children and families with autism. These children all have… $177,190
Fundacao De Apoio A Universidade De SAO Paulo Over the last 20 years, our research group at the Human Genome Center and Stem Cells (HUG-CELL) - Institute of Biosciences, University of São Paulo,… $175,306
University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bernie Devlin, Ph.D., Professor of Psychiatry, University of Pittsburgh will be responsible for modeling genetic data from the “Genomics of Autism in… $219,442

Quick answers

Who received award R01MH128813?

R01MH128813 was awarded to Icahn School Of Medicine At Mount Sinai by National Institute of Mental Health (National Institutes of Health) on March 3, 2022.

How much is award R01MH128813 worth?

$6,731,952 has been obligated on R01MH128813.

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