Bridges-round 2: evaluating the long-term impact of a family economic empowerment intervention on HIV risk prevention and care continuum outcomes among orphaned youth transitioning to young adulthood
Active Project Grant Awarded Last action
- Award ID
- R01MH128232
- Recipient
-
The Washington University UEI L6NFUM28LQM5
- Awarding agency
-
National Institute of Mental Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,528,015
Award facts
- Assistance listing
- 93.242 Mental Health Research Grants
- Completion date 93% complete
- Originally
- Place of performance
- University City, MO 63130, USA
Award details come from USAspending.gov.
Description
- Abstract
- Globally, adolescents and young adults (AYA; ages 14-29) represent 30% of HIV incidence cases among persons of reproductive age, with ~75% occurring in sub saharan africa (SSA). HIV incidence rises rapidly in SSA, as AYA leave school (often prematurely) and migrate for work and marriage. Older adolescents are more likely to experiment with health compromising behaviors that increase their vulnerability to HIV and sexually transmitted infections (stis). Young people orphaned by aids [ypoaids]), 80% of which live in SSA represent a particularly vulnerable and unique population. Most ypoaids in SSA experience immense hardships, including higher rates of HIV risk behavior and odds of HIV infection. These adversities cumulatively disrupt the developmental milestones for ypoaids and can compromise their health and emotional wellbeing. Notably, our team has had great success with implementing a 6-year, three-armed RCT that tested a family-based economic intervention, bridges (R01HD070727), among 1,383 primary school going adolescents in rural uganda (10-14 years of age at enrollment) who lost one or both parents to aids. With over 90% retention rate over a 6-year period (2012-2018), our findings show efficacy of this contextually-driven intervention significantly improving sexual health, school retention and performance, and mental health. Yet, two critical policy and programming questions related to HIV prevention and engagement in care continuum remain unaddressed: 1) longer-term effectiveness of bridges across ypoaids's life course is currently unknown but critically important because of unique vulnerabilities during the transition into young adulthood; and 2) self-reports of sexual health are unreliable, hence the need to integrate biomarkers to provide the most precise results of these highly relevant (but currently unknown) sexual health outcomes among our participants. Thus, the specific aims of the bridges- round 2 study are: aim 1. Examine the long-term impact of bridges on: HIV prevalence (measured via participant's HIV status) (primary outcome); and b) explore in secondary analyses the long-term impact of bridges on key developmental and behavioral outcomes (e.g., mental health, alcohol and drug misuse); aim 2. Elucidate the long-term effects of bridges on potential mechanisms of change, including: a) economic stability, viral suppression (for alhiv); prep use (for HIV negative adolescents), medical male circumcision (for boys); and b) young adult transitions; aim 3: qualitatively investigate participants' experiences with bridges that may have influenced engagement with the program, sexual risk-taking decisions, financial behaviors; experiences with developmental transitions; and perceptions on program sustainability; aim 4: to assess the long-term costs and benefits of bridges using formal economic evaluation. Our long-term goal is to translate knowledge into sustainable, theoretically-guided prevention and treatment efforts that promote the wellbeing of AYA affected by HIV/aids across the life course, in low-resource settings.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $489,799 | |
| Amendment | $57,106 | |
| Amendment | $57,106 | |
| Amendment | $513,947 | |
| Amendment | $513,947 | |
| Amendment | $513,947 | |
| Amendment | $584,035 | |
| Amendment | $584,035 | |
| Amendment | $584,035 | |
| Original award | $630,058 |
Show all 11
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The ST. Louis Integrated Health Network | $69,584 | |
| Makerere University College Of Health Sciences | $3,930 | |
| Makerere University College Of Health Sciences | $15,120 | |
| Reach The Youth Uganda | $177,152 | |
| Reach The Youth Uganda | $0 | |
| Mildmay Uganda LTD | $0 | |
| Makerere University College Of Health Sciences | $0 | |
| Reach The Youth Uganda | $0 | |
| Reach The Youth Uganda | $175,393 | |
| Mildmay Uganda LTD | $52,435 | |
| Makerere University College Of Health Sciences | $19,050 | |
| Mildmay Uganda LTD | $52,435 | |
| Makerere University College Of Health Sciences | $33,557 | |
| Makerere University College Of Health Sciences | $21,677 | |
| Reach The Youth Uganda | $157,465 |
Show all 15
Quick answers
Who received award R01MH128232?
R01MH128232 was awarded to The Washington University by National Institute of Mental Health (National Institutes of Health) on March 17, 2022.
How much is award R01MH128232 worth?
$4,528,015 has been obligated on R01MH128232.
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