Psyrat: extensible open-source software for applying generalizability theory to assess psychometric reliability of trial-wise scores and optimize tasks for rdoc
Active Project Grant Awarded Last action
- Award ID
- R01MH128208
- Recipient
-
University Of South Florida UEI NKAZLXLL7Z91
- Awarding agency
-
National Institute of Mental Health
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,779,271
Award facts
- Assistance listing
- 93.242 Mental Health Research Grants
- Completion date 86% complete
- Place of performance
- Tampa, FL 33620, USA
Award details come from USAspending.gov.
Description
- Abstract
- Neural biomarkers are an important focus of the nimh research domain criteria (RDOC) initiative, and they are increasingly used in the context of genomic studies and clinical trials. The use of biomarkers with strong psychometric reliability increases the likelihood of finding replicable effects, improves the validity of their interpretation, and decreases the likelihood of missing real phenomena. Although fundamental psychometric principles have long been a prominent concern among studies that use self-report measures, these principles are underappreciated in studies of psychopathology that use biological measures. This lack of attention to reliability limits the more widespread application of biomarkers in psychopathology and likely contributes to replication problems. Generalizability theory is a multifaceted framework for identifying sources of measurement error, and this framework is uniquely suited to assessing the reliability of biological measures and to optimizing tasks for reliability. A critical need exists for tractable software to facilitate the application of generalizability theory to time-frequency electroencephalography (EEG), event-related potentials (ERPS), facial electromyography (EMG), and electrodermal activity (EDA). The objective of this project in response to PAR- 18-930 on measurement tool development for RDOC is to (I) develop an extensive treatment of generalizability theory for psychopathology researchers, (II) develop accessible software to implement IT, (III) show how to apply these resources to optimize paradigms for individual-differences research, and (IV) disseminate the software with a user-friendly guide. This project will facilitate the routine evaluation of reliability through these specific aims: 1) design and implement generalizability theory formulas for evaluating group- and subject-level reliability for paradigm optimization; 2) develop software to implement these formulas with data from widely used psychophysiological software; 3) apply results to optimize three commonly studied tasks; and 4) develop online educational material on the application of these resources to novel paradigms and measures. This research project is innovative, because IT represents a substantive departure from standard practice by shifting the focus to the reliability of data from individuals, rather than groups, to identify sources of measurement error and minimize their impact. This work promotes best practices in reporting psychometric properties of biological measures and is applicable to data from any task with trial-wise scores. The resulting open-source toolbox, the psychophysiologist's reliability analysis toolbox (PSYRAT), can facilitate guidelines for optimizing paradigms, making decisions about individual-subject data, and grounding individual-differences questions (central to clinical research, especially for applications in precision medicine) in measures of reliability. The proposed process for guiding biomarker evaluation through high-quality psychometrics will pave the way for better selection of biomarkers and task development, ultimately improving the clinical utility of these biomarkers.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $581,579 | |
| Amendment | $580,944 | |
| Amendment | $589,164 | |
| Amendment | $589,164 | |
| Amendment | $576,175 | |
| Amendment | $576,175 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $643,035 | |
| Original award | $643,035 |
Show all 15
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| State University Of Iowa | $50,473 | |
| University Of California, Davis | $51,653 | |
| President And Board Of Trustees Of Santa Clara College | $53,515 | |
| University Of Florida | $29,022 | |
| University Of California, Davis | $51,653 | |
| University Of Florida | $26,561 | |
| President And Board Of Trustees Of Santa Clara College | $60,765 | |
| The University Of Iowa | $50,473 |
Quick answers
Who received award R01MH128208?
R01MH128208 was awarded to University Of South Florida by National Institute of Mental Health (National Institutes of Health) on August 4, 2022.
How much is award R01MH128208 worth?
$4,779,271 has been obligated on R01MH128208.
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