Improving outcomes in depression in primary care in a low resource setting

Active Project Grant Awarded Last action

Award ID
R01MH121632
Recipient
Awarding agency
Obligated
$9,379,196

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 89% complete
Originally
Place of performance
Boston, MA 02115, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Abstract depression is the leading mental health related contributor to the global burden of disease. We have shown in previous studies that generic antidepressant medications (adms) and brief psychological interventions such as our culturally adapted version of behavioral activation, the healthy activity program (HAP), are effective in achieving remission in primary care patients. However, not everyone responds to either intervention and similar aggregate outcomes can mask considerable individual variability in response. The goal of our proposed research is to see if we can enhance treatment outcomes for patients with moderate to severe depression by personalizing allocation to one of the two treatments; additionally, we aim to identify those patients who are unlikely to respond to either treatment and should be referred to specialist care. To achieve this, we will use machine learning to develop a precision treatment rule (PTR) based on a wide range of baseline moderators which are feasible to assess in routine care settings. Our primary hypothesis is that those patients randomized by chance to their optimal intervention as indicated by the PTR will be more likely to remit and recover than those who are not. Moreover, we hypothesize that using our PTR to select the optimal treatment for each individual patient will prove to be more cost-effective than leaving things to chance. We also plan to explore secondary questions, such as whether we can enhance our mediation tests by including the PTR in interactions with our purported mediators (moderated mediation). Further, we plan to explore whether we can enhance the prescriptive utility of our PTR via genotyping our sample and calculating polygenic risk scores based on very large sample genome-wide association studies. We will test these hypotheses in a controlled trial in primary care settings in india where we have a record of conducting depression treatment trials for two decades. We plan to randomize 1500 individuals to either HAP or ADM and generate our PTR on the first 1000 patients randomized and then test IT on the remaining 500 patients. This will be the first test of whether precision medicine can be used to enhance depression treatment outcomes through prediction of differential response to the two treatments recommended by the who for depression in primary care. Concurrently, we also should be able to identify baseline predictors of nonresponse to either of these two treatments, so as to identify patients who should be referred to specialist care at the outset. Our findings have the potential to make significant contributions to the prospect of optimizing the treatment of depression in primary care not just in india but also in primary care settings worldwide, and thus support the practice-related goals of nimh RFA- MH-18-701.

Transactions

Action Obligated Date
Amendment $0
Amendment $462,453
Amendment $462,453
Amendment $148,046
Amendment $148,046
Amendment $647,299
Amendment $647,299
Amendment Improving outcomes in depression in primary care $647,299
Amendment $1,254,765
Amendment $1,152,785
Amendment $1,152,785
Amendment $1,327,983
Original award $1,327,983
Show all 13

Subawards

Subrecipient Amount Awarded
Sangath Hypothesis or Research Question We hypothesize that the use of machine learning can develop a treatment selection algorithm that identifies the optimal… $780,058
The General Hospital Corporation Dr. Smoller and Dr. Karmel Choi will: 1. Contribute substantive expertise in statistical genetics, psychiatric genomics, and cross-population genetics to the… $195,569
Centre For Addiction And Mental Health The aim of this proposal is to compare a culturally adapted intervention based on behavioral activation and delivered lay counselors called the Healthy Activity… $25,330
Brigham & Womens Hospital Inc. Dr. Chunling Lu, at the Brigham and Women's Hospital in Boston, has an extensive experience in health care financing in developing countries, as she is a… -$10,087
All India Institute Of Medical Sciences Depression is the leading mental health related contributor to the Global Burden of Disease. Previous studies have shown that generic antidepressant medications… $148,046
The General Hospital Corporation Dr. Smoller and Dr. Karmel Choi will: 1. Contribute substantive expertise in statistical genetics, psychiatric genomics, and cross-population genetics to the… $38,140
Vanderbilt University Dr. Hollon is the Gertrude Conaway Vanderbilt Professor of Psychology at Vanderbilt University. He is an experienced treatment researcher with particular… $75,921
Brigham & Womens Hospital Inc. Dr. Chunling Lu, at the Brigham and Women's Hospital in Boston, has an extensive experience in health care financing in developing countries, as she is a… $80,871
Sangath Hypothesis or Research Question We hypothesize that the use of machine learning can develop a treatment selection algorithm that identifies the optimal… $0
Centre For Addiction And Mental Health The aim of this proposal is to compare a culturally adapted intervention based on behavioral activation and delivered lay counselors called the Healthy Activity… $0
All India Institute Of Medical Sciences Depression is the leading mental health related contributor to the Global Burden of Disease. Previous studies have shown that generic antidepressant medications… $0
Sangath Hypothesis or Research Question We hypothesize that the use of machine learning can develop a treatment selection algorithm that identifies the optimal… $0
Show all 12

Quick answers

Who received award R01MH121632?

R01MH121632 was awarded to President And Fellows Of Harvard College by National Institute of Mental Health (National Institutes of Health) on May 18, 2022.

How much is award R01MH121632 worth?

$9,379,196 has been obligated on R01MH121632.

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