Building safety guards into llms for trustworthy automatic simplification of medical documents

Active Project Grant Awarded Last action

Award ID
R01LM014600
Recipient
Awarding agency
Obligated
$1,400,945

Award facts

Assistance listing
93.879 Medical Library Assistance
Completion date 54% complete
Place of performance
Austin, TX 78759, USA

Award details come from USAspending.gov.

Description

Abstract
Texts describing medical advances are of keen interest to the general public. However, reliable medical evidence is largely disseminated in peer-reviewed journal articles describing new findings. Because such articles are wrięen in technical language intended for experts, this "primary literature" is effectively inaccessible to the general population. With very large language models (LLMS) like chatgpt now widely available, lay people are increasingly turning to them for medical information. One POTENTIALLY promising use is for LLMS to provide simplified versions of medical papers. However, while LLMS can capably simplify texts automatically, they can also still generate inaccurate, unsupported, and/or POTENTIALLY misleading information, posing a risk. This proposal seeks to develop novel natural language processing (NLP) technologies to mitigate risks and improve the reliability of LLM outputs for the task of medical text simplification. Given the high-stakes of healthcare information, we focus on building controllable, transparent LLMS that are moderately sized, and design tools that enable communities to strike a balance between using LLMS safely and perceiving their outputs critically, while (POTENTIALLY) improving health literacy by eventually empowering the public with more reliable access to high-quality, newly published medical findings. We propose several methodological safeguards. To begin, we will design the first error detection model for LLM-generated simplifications of medical texts, trained with expert-annotated data focusing on factual correctness. This tool will then allow US to build safer knowledge distillation methods, i.e., training much more efficient, smaller models on examples elicited from massive, closed models like GPT-4 calibrated by estimated confidence of their correctness. With full access to the parameters of the distilled model, we propose innovative ways to improve the factuality and readability of the output, and to estimate the model's (UN)certainty of its own output. We will then integrate these safety guards into a prototype, such that they can be evaluated by medical experts and lay readers.

Transactions

Action Obligated Date
Amendment $336,527
Amendment $336,838
Amendment $0
Amendment $0
Amendment $363,790
Original award $363,790

Subawards

Subrecipient Amount Awarded
Georgia Institute Of Technology Building Safety Guards into LLMs for Trustworthy Automatic Simplification of Medical Documents. $204,544

Quick answers

Who received award R01LM014600?

R01LM014600 was awarded to University Of Texas At Austin by National Institute of Environmental Health Sciences (National Institutes of Health) on September 18, 2024.

How much is award R01LM014600 worth?

$1,400,945 has been obligated on R01LM014600.

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