Project Grant R01HL187986
- The National Heart, Lung, and Blood Institute awarded Vanderbilt University Medical Center $874,014 on July 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the relationship between gut microbiota, metabolite composition, and salt sensitivity of blood pressure. The research quantifies salt sensitivity of blood pressure as the change in 24-hour ambulatory mean arterial pressure from one week of high-salt to one week of low-salt diet in 50 adult subjects...
- The National Heart, Lung, and Blood Institute awarded Augusta University Research Institute, Inc. $1,518,002 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate posttranslational control of vascular smooth muscle cell identity and vascular health through neddylation mechanisms in coronary artery disease. The award funds research into the role of neddylation—specifically NEDD8 activating enzyme 1 (NAE1)-mediated protein modification—in vascular...
- The National Heart, Lung, and Blood Institute awarded the University of South Carolina $100,228 on December 31, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on the mechanistic pathways linking hypertension, autoimmunity, and chronic psychological stress. The research tests whether chronic stress exacerbates immune system activation and hypertension in a female hypertensive mouse model of systemic lupus erythematosus (NZBWF1). The investigator's...
- The National Heart, Lung, and Blood Institute awarded $248,976 to Augusta University Research Institute, Inc. on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify novel and conserved regulators of cardiomyocyte polyploidy using Drosophila genetic models and mammalian cardiomyocytes. The research addresses how mammalian cardiomyocytes transition from proliferation to growth during adolescence through whole genome duplication. The recipient will conduct...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $1,636,543 on March 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the ubiquitin editor A20 in regulating sodium transport and the hypertensive response through selective actions in kidney epithelial cells and tubules. The research addresses the mechanisms through which A20 suppresses inflammatory cytokines that modulate...
- The National Heart, Lung, and Blood Institute awarded New York University $6,557,762 on September 12, 2025, under CFDA 93.837 (Cardiovascular Diseases Research) to investigate the relationship between the gut microbiome and coronary artery calcium as a measure of subclinical coronary atherosclerosis in Asian American, Native Hawaiian, and Pacific Islander adults. The research aims to characterize coronary atherosclerotic burden in 4,000 ASA-NHPI adults aged 40 and older, integrating bacterial,...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Virginia $702,191 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic biomedical research on cell volume regulatory mechanisms and their role in autonomous aldosterone production. The research targets primary aldosteronism, a genetic condition characterized by excessive aldosterone production independent of the...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Rush University Medical Center $749,087 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate sodium-independent mechanisms of edema in nephrotic syndrome. The project studies the role of circulating angiopoietin-like 4 (ANGPTL4), specifically its C-fragment, as a mediator of skin capillary endothelial permeability in nephrotic...
- The National Institutes of Health National Heart Lung and Blood Institute awarded The Medical University of South Carolina $188,568 under the Cardiovascular Diseases Research program (CFDA 93.837) on April 1, 2026, to investigate skeletal muscle microvascular dysfunction in systolic heart failure. The award funds research comparing pre- and post-exercise assessments of noninvasive measures of skeletal muscle microvascular function in the distal leg alongside invasive hemodynamic monitoring to...
- The National Institutes of Health National Heart Lung and Blood Institute awarded Louisiana State University Health Sciences Center New Orleans $1,008,719 on April 6, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to screen and validate microRNA targets for neurogenic hypertension. The work addresses treatment-resistant neurogenic hypertension, which accounts for a substantial share of resistant hypertension cases and stems from increased sympathetic outflow from the...
The National Heart, Lung, and Blood Institute awarded Augusta University Research Institute, Inc. $707,903 on August 21, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the gut-immune-kidney axis in salt-sensitive hypertension and renal end-organ damage. The research addresses sex-specific mechanisms by which gut microbiota and their metabolites modulate immune responses contributing to salt-sensitive hypertension and kidney disease. The project will conduct mechanistic studies in male and female Dahl salt-sensitive rats, with translational analysis using stored biological samples from humans on high-salt diets. The grant tests the hypothesis that sex differences in gut microbiota function produce pathological metabolites in males (carnitine and trimethylamine N-oxide) and protective metabolites in females (short-chain fatty acids), with these metabolites altering T cell activation to influence blood pressure and kidney function. Aim 1 evaluates whether sex-specific microbiota differences alter the severity of salt-sensitive hypertension and renal damage through microbiota transfer studies. The period of performance runs from August 21, 2026, through April 30, 2031. Work is performed in Augusta, Georgia. The award is structured as a Project Grant, a standard NIH assistance type for competitive research funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $707.9k | 8/25/26 |