Project Grant R01HL185679
- Federal Project Grant Award Summary Vitalant Research Institute received a $262,500 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 15, 2025, with completion targeted for August 31, 2027. The award funds research aimed at defining the drivers of mitochondrial DNA (mtDNA) levels in blood components and investigating their impact on transfusion-related acute lung injury (TRALI). The...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $776,881 Project Grant to Loma Linda University on June 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct basic research on cerebral blood flow autoregulation in newborns. The research will be conducted in Loma Linda, California, with an anticipated completion date of February 28, 2030. The primary deliverable is the generation of fundamental scientific knowledge...
- Federal Project Grant Award Summary Award Details: The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $392,952 to The Washington University in St. Louis, Missouri, with an award date of August 1, 2025, and a completion date of April 30, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). Research Products and Services: This K23 mentored career development award will deliver a prospective cohort study investigating the role of blood-brain...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $731,827 Project Grant to J. David Gladstone Institutes, effective September 1, 2025 through June 30, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). The research project, "Mechanisms of Oxygen Toxicity," focuses on understanding how excess oxygen (hyperoxia) damages cellular tissue across multiple disease states, including hyperoxic lung injury,...
- Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Florida's Division of Sponsored Research a $159,560 Project Grant effective December 1, 2026, through June 4, 2029, under the Cardiovascular Diseases Research program (CFDA 93.837). The grant funds postdoctoral research training and investigation into novel extracellular nicotinamide phosphoribosyltransferase (eNAMPT) targeting as a therapeutic approach to mitigate traumatic brain injury (TBI)-induced...
- Federal Project Grant Award Summary Bloodworks (doing business as Puget Sound Blood Center and Program) received a $504,644 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 15, 2025, with completion targeted for July 31, 2030. This five-year research initiative focuses on investigating platelet-mediated CD8+ T cell suppression mechanisms in sepsis-associated chronic...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $776,791 Project Grant to The Washington University on June 4, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports research investigating how sequence changes in intrinsically disordered regions (IDRs) of cardiac troponin affect protein function and cardiac contraction regulation. The project, which extends through April 30, 2029, addresses a critical gap in...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Children's Hospital of Philadelphia Research Institute a $445,000 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) for a three-year period from July 15, 2025, through June 30, 2028. This award supports research determining genetic mechanisms that drive in vitro hematopoiesis, specifically investigating how the tropomyosin 1 (TPM1) gene impacts the development of...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Washington University a Project Grant of $764,681 under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 1, 2026 through January 31, 2030. This award funds mechanistic research investigating cardiac fibroblast biology and fibrotic responses in heart failure. The research deliverables include comprehensive characterization of a novel stem cell antigen-1-expressing cardiac...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Emory University $110,635 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 12, 2025, for a project grant extending through August 31, 2027. The award funds research investigating the role of blood rheology and transfusion interventions in microvascular thrombosis during sepsis. The project will utilize microfluidics assays to characterize how red blood cell (RBC) aggregation and...
The National Heart, Lung, and Blood Institute (NHLBI) awarded Bloodworks a Project Grant totaling $724,351 (Award Date: July 1, 2026; Completion Date: April 30, 2030) under the Cardiovascular Diseases Research program (CFDA 93.837). This research project, titled "Metabolically Aberrant Extracellular Mitochondria and Oxidative Endotheliopathy After Traumatic Brain Injury," investigates the mechanisms by which extracellular mitochondria (ExMT) released from injured brains cause endothelial cell injury during acute traumatic brain injury (TBI). The funded research will generate scientific findings regarding ExMT-induced subcellular changes, including endocytosis pathways, endoplasmic reticulum oxidative stress, unfolded protein responses, and mitochondrial autophagy processes. The project will deliver in vitro experimental research findings and evaluate the efficacy of therapeutic agents designed to block ExMT-induced endotheliopathy. These research products will advance understanding of hemostatic dysregulation and endothelial dysfunction in TBI, with potential implications for addressing consequent complications including cerebral edema, elevated intracranial pressure, acute lung injury, and systemic coagulopathy. The award supports basic science research conducted at Bloodworks' Seattle, Washington facility, contributing to the NHLBI's broader mission of preventing and treating heart, lung, and blood diseases through competitive, peer-reviewed research funding.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $724.4k | 6/19/26 |