Project Grant R01HL183628
- The National Institutes of Health National Heart Lung and Blood Institute awarded Ann & Robert H Lurie Children's Hospital of Chicago $876,614 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a multisite prospective cohort study advancing acute respiratory infection treatment in pediatric invasive home mechanical ventilation. The research will enroll 400 children in English and Spanish language families using long-term home mechanical...
- The National Heart, Lung, and Blood Institute awarded Seattle Children's Hospital, doing business as Seattle Children's Research Institute, $1,839,440 on August 5, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate how heavy chain hyaluronan and TSG-6 modulate lung inflammation during respiratory syncytial virus (RSV) infection. The research examines the extracellular matrix's role in RSV pathogenesis, focusing on age-dependent inflammation in young children....
- The National Institutes of Health National Heart, Lung, and Blood Institute awarded The Children's Hospital of Philadelphia $1,741,543 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate lung injury in pediatric hematopoietic cell transplant recipients. The research examines molecular mechanisms of pulmonary toxicity in pediatric HCT recipients, who experience lung injury in up to 40% of cases with mortality rates of 40% when requiring...
- The National Heart, Lung, and Blood Institute awarded Children's Research Institute $1,818,088 on July 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate how postnatal hypoxemia—reduced blood oxygen levels present in cyanotic congenital heart disease—impacts cardiac maturation and surgical recovery outcomes in pediatric patients. The project will examine the interaction between hypoxemia, myocardial immaturity, and postoperative complications through...
- The National Institutes of Health National Heart, Lung, and Blood Institute awarded The Children's Hospital of Philadelphia $360,418 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop integrated host-microbe classifiers for diagnosing lower respiratory tract infection in children using metagenomic next-generation sequencing applied to non-invasive samples including nasopharyngeal swabs and whole blood. The project addresses diagnostic gaps in pediatric...
- The National Heart, Lung, and Blood Institute awarded Seattle Children's Hospital $1,736,235 on August 15, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate sleep health and its relationship to childhood systemic lupus erythematosus (CSLE) symptoms within the sociocultural and neighborhood contexts of affected youth. The research examines associations between sleep health dimensions—including duration, efficiency, regularity, and daytime sleepiness—and CSLE...
- The National Institutes of Health National Heart Lung and Blood Institute awarded Ann & Robert H Lurie Children's Hospital of Chicago $781,860 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the novel role of neutrophils in mediating endothelial regeneration and vascular repair in sepsis and acute respiratory distress syndrome (ARDS). The research addresses ARDS pathology, specifically endothelial barrier injury and increased vascular...
- The National Heart, Lung, and Blood Institute awarded Seattle Children's Hospital $893,522 on May 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate air pollution exposure in children with cystic fibrosis and its contribution to health disparities, particularly among Hispanic children. The award funds the Home Air Pollution in Children with Cystic Fibrosis (HEROIC-CF) study, which will use the CF Foundation Patient Registry and the University of Washington...
- The National Heart, Lung, and Blood Institute awarded Cincinnati Children's Hospital Medical Center $331,340 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to develop and validate dynamic free-breathing 129Xe MRI as a non-invasive functional lung imaging tool for pediatric populations including neonates, infants, toddlers, and young children. The project addresses limitations of current clinical assessment methods for pediatric lung diseases such as...
- The National Institutes of Health National Heart Lung and Blood Institute awarded New York University $201,728 on March 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research examining mechanisms contributing to functional recovery across the care cascade for respiratory failure. The research addresses how patient-level social determinants recorded at hospital admission, unit-level care processes during hospitalization, and community-level environmental...
The National Heart, Lung, and Blood Institute awarded Seattle Children's Hospital $930,637 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 1, 2026, to conduct PROSPER (Pulmonary Recovery and Outcomes After Severe Pediatric Respiratory Illness), a multicenter prospective longitudinal cohort study examining how impaired pulmonary function contributes to physical and health-related quality-of-life morbidity among children surviving acute respiratory failure. The study will enroll children treated with invasive or non-invasive mechanical ventilation for acute parenchymal or lower airway disease and assess pulmonary function, physical activity, sleep, resting heart and respiratory rate, and patient- and caregiver-reported outcomes serially over one year following hospital discharge. The research addresses a gap in understanding lung function recovery trajectories following acute respiratory illness in pediatric populations, where small prior studies were limited by high attrition, single-timepoint assessment, and applicability only to children six years and older without cognitive impairment. The objectives include describing recovery trajectories of pulmonary function, identifying risk factors for poor long-term outcomes, and determining targets for interventions to improve outcomes in this growing population. The award funds work performed at Seattle Children's Hospital in Seattle, Washington, with a period of performance from September 1, 2026, through May 31, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $930.6k | 8/27/26 |