Project Grant R01HL181902

Award Date 7/20/25
Completion Date 6/30/29
Dollars Obligated $622K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Irvine, CA 92697, USA
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  1. Engineering a single-walled carbon nanotube field effect transistor (SWNT FET) system to record PKA-C dynamics with 35 ns time resolution, using inkjet and 3D printing for rapid design-build-test cycles.

  2. Characterizing the catalytic machinery of wild-type PKA-C, including nucleotide binding, cleft opening/closing, and requirements for pH and metal ions.

  3. Examining the phosphorylation of well-studied cardiac substrates by wild-type and disease-associated mutant PKA-C, to understand the link between aberrant PKA-C activity and cardiac dysfunctions like dilated and hypertrophic cardiomyopathy.

The research aims to uncover a dynamic portrait of PKA-C in both diseased and normal cardiac physiologies, with potential to have broad impact within the biomedical community.

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