Project Grant R01HL180371
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $761,042 to the University of Pittsburgh to conduct research on the mechanisms driving medial arterial calcification (MAC) in peripheral artery disease (PAD). The key objectives are to: 1) define how the DNA damage response promotes vascular calcification, and 2) determine how reduced adenosine production alters arginine methylation to upregulate osteogenic gene...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $489,644 to Vanderbilt University to develop non-cytotoxic drug-coated balloon (DCB) therapies to improve long-term treatment outcomes for peripheral arterial disease (PAD). The goal is to create peptide-based DCB therapies that can be delivered during angioplasty procedures to block inflammatory signaling and inhibit smooth muscle cell proliferation, which are...
- The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $159,980 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Regents of the University of California, San Francisco (UCSF) for the period of March 1, 2025 to August 31, 2026. The grant will fund research to investigate the role of the protein Klotho in the pathogenesis of medial arterial calcification, which is a major risk factor for limb amputation in patients with peripheral artery disease...
- The National Heart, Lung, and Blood Institute awarded a $700,019 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Research Institute at Nationwide Children's Hospital in Columbus, Ohio. The grant aims to develop a novel dual-phase PET/CT imaging approach using 18F-NAF to comprehensively assess peripheral artery disease (PAD) in patients with and without diabetes. The key goals are to: 1) characterize the stages of peripheral atherosclerosis targeted by...
- This federal Project Grant award of $687,517 from the National Heart Lung and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) supports research to elucidate the role of the gene Leiomodin1 (LMOD1) in the formation of mature blood vessels, which is critical for restoring blood flow in peripheral artery disease (PAD). The research, to be conducted by the University of Alabama at Birmingham from May 2025 to February 2030, aims to determine how LMOD1 regulates the vascular...
- This Project Grant award of $528,179, awarded by the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research conducted by the University of Miami to investigate reprogramming of monocytes to improve neovascularization in peripheral arterial disease and critical limb ischemia. The key objectives are to: 1) determine if extracellular vesicles mediate the systemic effects of monocyte reprogramming, and 2) investigate how reduced expression of the...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports the development of a lesion-targeted nanotherapeutic to address vascular smooth muscle cell (VSMC) dysfunction and mitigate neointimal hyperplasia (NIH), which is a significant issue arising from vascular damage during interventions. The project aims to integrate in vitro transcribed CARMN RNA (a long non-coding RNA critical...
- This Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The $138,523 award to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System) will fund research to investigate the distinct mechanisms underlying medial and intimal calcification in blood vessels, which are associated with increased cardiovascular disease risk. The research aims to systematically...
- This federal Project Grant award of $701,791 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of neddylation, a post-translational modification, in protecting endothelial cell integrity and function. The research aims to establish the pathophysiological significance of neddylation in the endothelium and identify key downstream effectors. The University of Nebraska, Lincoln is the awardee and will utilize...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
This $689,928 Project Grant awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a novel method for delivering localized chelation therapy to remove arterial calcification in patients with peripheral artery disease (PAD). The project will leverage the awardee's University of Nebraska expertise in evaluating over 1,000 human lower extremity arteries and a preclinical large animal model of arterial calcification. The key objectives are to: 1) Use the awardee's biobank of calcified human arteries to develop a localized EDTA chelation strategy to reduce calcific lesions, and 2) Employ the awardee's swine model of peripheral artery calcification to determine the safety and effectiveness of the localized EDTA treatment. The award has an ultimate completion date of June 30, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $689.9k | 9/5/25 |