Project Grant R01HL179131
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $1,137,883 to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Cardiovascular Diseases Research program (CFDA 93.837). The award, effective April 1, 2026, through January 31, 2033, funds research into the "Dynamics and Plasticity of the Hematopoietic Stem Cell Niche." The project will investigate how the bone marrow and...
- This five-year Project Grant, awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), provides $153,117 in obligated funding beginning August 1, 2025, through July 31, 2030. The award supports a physician-scientist's career development and independent research program focused on improving hematopoietic stem and progenitor cell (HSPC) transplantation outcomes through investigation of cellular crosstalk mechanisms between...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Boston Children's Hospital a $5.96 million Project Grant on August 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct a multi-omic investigation optimizing hematopoietic stem cell transplantation (HCT) outcomes. The five-year research initiative, scheduled for completion by May 31, 2030, will deliver mechanistic and translational science research aimed at improving...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Trustees of Columbia University in the City of New York $1,382,687.53 under the Cardiovascular Diseases Research program (CFDA 93.837) for a project examining epitranscriptomic regulation in hematopoietic stem cell (HSC) niche generation and regeneration. The award, obligated on August 5, 2025, with a completion date of March 31, 2026, supports basic research investigating how N6-methyladenosine...
- Federal Project Grant Award Summary Boston University Medical Campus received a $150,342 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 30, 2026, with completion targeted for June 30, 2029. The award funds research investigating the mechanisms of a conserved niche endothelial program that directs hematopoietic stem cell (HSPC) migration into bone marrow during stem cell...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $1,175,924 (awarded April 1, 2026; completion January 31, 2033) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on hemogenic mesoderm heterogeneity, regulation, and function. The research investigates the molecular and transcriptional mechanisms underlying early embryonic hematopoietic...
- Federal Project Grant Summary The University of Florida Division of Sponsored Research received a $597,817 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2026 through April 30, 2030. The award funds research to develop novel resources and methodologies for improving hematopoietic stem cell (HSC) transplantation outcomes, with the goal of expanding the donor pool for patients with...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $166,644 to The Trustees of Columbia University in the City of New York (Health Sciences Division) on July 16, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). The award supports research investigating inflammatory responses in human hematopoietic stem cells (HSCs) with a focus on understanding how aging and clonal hematopoiesis—specifically TET2 mutations—alter...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $521,101 Project Grant to the University of Wisconsin–Madison, with an award date of June 15, 2026, and completion date of February 28, 2031, under the Cardiovascular Diseases Research program (CFDA 93.837). The research focuses on defining the mechanisms by which hematopoietic stem cells (HSCs) acquire macrophage-associated markers through trogocytosis—a cellular membrane transfer mechanism—and...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Massachusetts a $425,971 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective July 6, 2026, through June 30, 2028, to develop a biomaterials-integrated microphysiological bone marrow chip model. The project aims to create a physiologically relevant preclinical system that recapitulates the structural and functional interdependence of bone and bone marrow...
This Project Grant, awarded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), provides $703,389 in federal funding to New York Blood Center, Inc. for research examining sex dimorphism in the bone marrow niche and its effects on hematopoietic stem cell transplantation (HSCT). The award, effective July 15, 2026, through April 30, 2030, supports fundamental and translational research designed to advance understanding of how biological sex differences in bone marrow environments influence the success of blood stem cell transplants used to treat blood diseases and immune disorders. The research deliverables include mechanistic studies identifying how sex-specific gene expression—particularly the histone demethylase gene KDM5C and its regulation of CXCL12 signaling in mesenchymal stromal cells—contributes to sex differences in hematopoietic engraftment. The project encompasses three primary research aims: determining cellular mechanisms of KDM5C regulation in sex dimorphism, elucidating molecular pathways linking KDM5C-CXCL12 signaling to sex differences in bone marrow function and engraftment outcomes, and evaluating the therapeutic potential of manipulating bone marrow niche sex dimorphism to improve HSCT clinical efficacy. Findings are expected to generate evidence supporting sex-matched donor-recipient selection strategies and therapeutic interventions to optimize transplantation outcomes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $703.4k | 7/10/26 |