Project Grant R01HL178923
- This $673,512 federal Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under CFDA Program 93.837 - Cardiovascular Diseases Research. The grant will fund research by the University of California, San Francisco (UCSF) to investigate the neural mechanisms underlying breathing regulation, with a focus on understanding the paradox of neural inhibition in the respiratory pacing mechanism. The research aims to determine whether breathing rhythm arises from an...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $497,628 to The Medical College of Wisconsin, Inc. to investigate the role of pulmonary vagal sensory neurons in the neural control of breathing in preterm infants with bronchopulmonary dysplasia (BPD). The research aims to elucidate the dose- and duration-dependent effects of neonatal hyperoxia exposure on breathing function...
- This federal Project Grant award, valued at $569,695.00, was issued by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program. The award supports research to investigate the mechanisms and therapeutic potential of phrenic proprioceptors (sensory neurons) after spinal cord injury, with the goal of restoring respiratory neural function and improving breathing. The research, conducted by Marquette University, aims to test the...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $644,687 to the University of Missouri System to conduct research on a neural circuit in the brain that contributes to hypertension associated with obstructive sleep apnea. The research aims to determine how this "orexin-CRH-NTS" circuit facilitates the peripheral chemoreflex and leads to sympathoexcitation and hypertension,...
- This federal Project Grant award in the amount of $149,348 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Florida. The award funds research to investigate the cellular mechanisms involved in acute-intermittent hypercapnic-hypoxia induced phrenic motor plasticity. Specifically, the project aims to monitor phrenic nerve activity in anesthetized rats as a proxy for diaphragm muscle...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $807,067 to the University of Virginia to pioneer the quantitative documentation of the human respiratory kinematic profile. The project aims to address a critical gap in contemporary physiological monitoring - the inability to quantify labored breathing, which contains vital prognostic information not captured by conventional monitoring. The study will...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $148,460 project grant to the University of Florida (UF) to conduct research on the daily and circadian regulation of respiratory plasticity in freely behaving rats. The project, which runs from February 2025 to September 2027, aims to investigate how the daily rest/active cycle and local circadian clocks within phrenic motor neurons influence acute intermittent...
- This federal Project Grant award of $146,703 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the cellular and molecular basis of respiratory chemoreception dysfunction in hypertension. The awardee, the University of Connecticut, will use a combination of electrophysiology and imaging approaches to characterize the CO2/H+ response of neurons, astrocytes, and arterioles in the...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), provides $421,800 to Midwestern University to explore the effects of chronic intermittent hypoxia on cholinergic modulation at hypoglossal motoneurons. The project aims to determine changes in muscarinic acetylcholine receptor expression and cholinergic inputs to hypoglossal motoneurons in neonatal and adult mice exposed to chronic...
- This federal Project Grant award, provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to investigate the neural mechanisms by which inspiratory muscle training (IMT) reduces blood pressure in patients with obstructive sleep apnea (OSA). The $721,237 award to the University of California, Los Angeles (UCLA), spanning from September 1, 2025 to June 30, 2029, will employ resting-state functional magnetic...
This federal Project Grant award of $794,661 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program aims to define how higher brain regions interact with brainstem circuits to produce disordered breathing, with a focus on dyspnea - a persistent sensation of breathing discomfort. The project, titled "SMILE (SICKLE CELL DISEASE MICROBIOLOGIC AND IMMUNOLOGIC LINKS TO HEALTH) - RESPIRATORY CONTROL", will utilize intracranial EEG (iEEG) from patients with implanted electrodes to access deep brain sources and resolve the sensory and affective components of dyspnea. The key objectives are to determine causality between respiratory-related brain oscillations (RRBO) and the breathing cycle, validate RRBO as a neural marker of dyspnea, and use direct electrical stimulation to target key brain regions to reduce dyspnea. This research aims to guide safer treatments for respiratory disorders by identifying cortical mechanisms that shape the perception of dyspnea without impairing ventilation. The project period runs from September 19, 2025 through June 30, 2030 and is being conducted by Emory University.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $794.7k | 9/18/25 |