Project Grant R01HL178712
- This federal Project Grant award of $709,902 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to establish a well-characterized cohort of individuals with post-tuberculosis lung disease (PTLD) in Uganda. The key objectives are to determine whether sex, HIV serostatus, and air pollution exposure are associated with distinct lung function and chest imaging phenotypes of PTLD. The award will support the enrollment of 650 post-TB and 165 non-TB...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is supporting a research project titled "Targeted Implementation of Pulmonary Rehabilitation for Post-Tuberculosis Lung Disease". The $187,461 award will be used to 1) define the clinical patterns of post-tuberculosis lung disease (PTLD) and associated outcomes to identify those most in need of pulmonary rehabilitation (PR); 2) develop a structured process for...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $2,513,201 in funding to The Trustees of the University of Pennsylvania to research excess cardiovascular inflammation in tuberculosis (TB) and HIV. The overarching hypothesis is that TB promotes pulmonary inflammation leading to subclinical vascular pathology, increasing the risk of major cardiovascular events in TB survivors. The research will investigate...
- This $854,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to assess post-tuberculosis (TB) lung disease in TB patients with and without HIV coinfection. The project will utilize novel positron emission tomography (PET) imaging techniques, such as 11C-rifampin PET, to longitudinally profile lesional characteristics and antibiotic exposures in animal models...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $897,448 to The Johns Hopkins University to conduct research on the causality of post-tuberculosis (TB) lung disease in rural Uganda. The study aims to evaluate lung function and respiratory symptoms both before and after TB diagnosis to better understand how much post-TB sequelae reflect the TB disease...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,136,143 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to study post-tuberculosis lung disease (PTLD) in youth with and without HIV globally. The project will leverage the Tuberculosis Sentinel Research Network (TB-SRN) in 11 countries to establish the prevalence of PTLD in youth, identify modifiable risk factors, and assess the impact on quality of life....
- This $136,718 Project Grant award from the National Institutes of Health's Fogarty International Center (CFDA 93.989 - International Research and Research Training) supports a study to investigate the long-term respiratory health impacts of pulmonary tuberculosis in children and adolescents in The Gambia. The project, led by Principal Investigator Dr. Esin Nkereuwem from the Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, aims to: 1) characterize...
- This Project Grant award for $1,063,324 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on CD4+ T cell immunity in the respiratory tract, with a focus on understanding the mechanisms underlying host defense against extracellular pathogens, particularly in the area of Type 17 cytokines and tissue resident memory CD4+ T cells. The research will utilize murine and primate respiratory tract samples to assess the metabolic...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, will support research to investigate the use of chest radiography (CXR) to identify young individuals with early stages of tuberculosis (TB) in a community-based active case-finding program in Lima, Peru. The $242,376 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, will fund a 2-year study to...
- This Project Grant award of $821,087 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research to examine the relationship between latent tuberculosis infection (LTBI) and the risk of developing diabetes mellitus and cardiovascular disease. The key objectives are to: 1) Estimate the association between LTBI and indicators of diabetes and cardiovascular disease; 2) Determine if established...
This $830,261 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research program) supports research on post-tuberculosis (TB) lung disease among individuals successfully treated for TB in Lima, Peru. The project, titled "Host- and Pathogen-Specific Risk Factors for Post-Tuberculosis Lung Disease among People Successfully Treated for TB in Lima, Peru: BEAT-PTLD," will evaluate 1,000 TB patients and 291 community controls 2-3 years after initial TB diagnosis using spirometry, CT scans, and echocardiography to characterize post-TB lung disease phenotypes. The researchers aim to estimate the relative risks of potential determinants of post-TB lung disease measured at TB diagnosis and develop a predictive model to identify high-risk individuals. This award, with a performance period from September 2025 to June 2030, is part of broader efforts by the National Institutes of Health to advance scientific understanding and prevention of long-term respiratory complications following successful TB treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $404.9k | 9/20/25 | ||
| Not listed | $425.4k | 9/19/25 |