This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $2,377,618 to Brigham & Women's Hospital Inc. to conduct research focused on characterizing COPD-related alternative splicing in human airway epithelial cells (HAECs). The key products and services to be delivered under this 4-year grant include: 1) generating the first HAEC genome-wide splicing QTL maps to identify COPD GWAS...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $131,783 to Brigham & Women's Hospital Inc. from February 1, 2025 to December 31, 2029. The grant supports three main objectives: Developing and implementing a protocol to collect biospecimens before and after bronchoscopic lung volume reduction (BLVR) procedures to identify blood and bronchoalveolar lavage fluid biomarkers...
This federal Project Grant award of $1,405,336.00 was made on September 1, 2024 by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research at Florida International University (FIU) focused on understanding the pathophysiological mechanisms of HIV-associated chronic obstructive pulmonary disease (COPD). The key research objectives are to: 1) Identify how HIV Tat protein and cigarette smoke exposure alter the...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), will support research into post-transcriptional regulatory networks in chronic obstructive pulmonary disease (COPD). The total funding amount is $708,063.00, with a project period from May 1, 2025 to February 28, 2030. The key objectives of this research project are to: 1) develop a method to identify RNA-binding protein (RBP) to RNA...
The federal Project Grant award R01HL174838, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a population-based analytics and data infrastructure to evaluate the impact of non-COPD medications on outcomes for patients with chronic obstructive pulmonary disease (COPD). The total award amount is $794,681, with a project period from September 17, 2024 to June 30, 2029. The primary objectives are to...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837) will fund a $116,625 research study to characterize changes in airway and chest wall deformation in patients with chronic obstructive pulmonary disease (COPD). The study will leverage established datasets from nationwide longitudinal lung studies to develop normative models of airway and chest wall deformation metrics, identify...
This $762,867 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program supports research to investigate the role of the protein cofilin-1 in mitochondrial quality control mechanisms that impact airway epithelial dysfunction in chronic bronchitis, a subtype of chronic obstructive pulmonary disease (COPD). The project aims to determine how the loss of cofilin-1 affects mitochondrial dynamics, mitophagy, and...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $572,076 to Pennsylvania State University (Penn State) to conduct a multi-omic characterization study of chronic obstructive pulmonary disease (COPD) in females. The research aims to gain novel insights into the genetic and molecular mechanisms underlying sex differences in COPD prevalence, pathology, and symptoms. Key...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research (CFDA 93.837) program, provides $2,020,089 to The Johns Hopkins University to conduct research on the role of viral infections and autoantibodies in the progression of chronic obstructive pulmonary disease (COPD). The key objectives are to: 1) Assess associations between baseline viral antibodies and longitudinal lung function decline in COPD patients, 2)...
The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), awarded a $498,000 Project Grant to the Research Institute at Nationwide Children's Hospital (RINCH) on February 21, 2025. The grant, titled "Molecular Analysis of Airway Secretory Cells in Health and Disease," aims to advance the understanding of chronic obstructive pulmonary disease (COPD), the third leading cause of death in the U.S. and worldwide....