Project Grant R01HL177670
Award Date
7/15/25
Completion Date
5/31/29
Dollars Obligated
$417K
Federal Agency
National Heart Lung and Blood Institute
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Dallas, TX 75390, USA
Similar Awards
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $816,079 to the University of Texas Health Science Center at Houston to conduct proteomic profiling research on heart failure in Hispanic/Latino populations. The key objectives are to: 1) Identify circulating protein biomarkers and signatures associated with impaired cardiac function and the progression to clinical heart failure, 2)...
The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, awarded a $156,600 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The University of Texas Southwestern Medical Center (UT Southwestern). The 5-year grant will support research to define the role of the PHF7 protein in driving cardiac reprogramming and improving heart function following a myocardial infarction. Specifically, the project aims to: 1) Characterize...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $554,737 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Texas Southwestern Medical Center, with a project period from Sep 1, 2024 to Jun 30, 2029. The objective of this grant is to leverage multi-omic technologies to identify novel pre-transplant biomarkers associated with clinically significant rejection within the first year following heart transplantation. The research will involve proteomic...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $506,665.57 Project Grant under CFDA 93.837 - Cardiovascular Diseases Research to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on the role of the TSPAN14 gene in coronary artery disease (CAD) pathogenesis. The project aims to determine how genetic variations in the 10q23 enhancer region regulate TSPAN14 expression in vascular endothelial cells and monocytes, and elucidate the...
This Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research, provides $815,229 to The University of Texas Southwestern Medical Center to conduct advanced research on cardiovascular disease susceptibility and resilience in Black Americans. The key objectives are to: 1) Identify proteins and protein networks associated with clinical and subclinical cardiac dysfunction, 2) Pinpoint proteins and networks linked to...
This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The Johns Hopkins University provides $1,402,988.66 in funding from September 1, 2024 to July 31, 2028. The project aims to investigate the role of protein kinase G (PKG) and the ubiquitin ligase CHIP in enhancing the degradation of mutant transthyretin to attenuate cardiac amyloidosis. Key objectives include: Testing if PKG stimulation or expression of a CHIP...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $149,804 to The University of Texas Southwestern Medical Center to study the native in situ structure of myofibrils within intact human cardiomyocytes derived from induced pluripotent stem cells. The research aims to use advanced cryo-electron tomography techniques to directly observe conformational alterations in cardiac b-myosin due to...
The University of Arizona was awarded a $625,316 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to investigate the role of RNA methylation and translational regulation in the oxidative stress response of heart failure. The research aims to elucidate how the YTHDF2 protein binds to methylated NRF2 mRNA to selectively induce its translation under oxidative stress, a process that may be impaired in end-stage heart failure. The...
This Project Grant award in the amount of $121,500.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), to The University of Texas MD Anderson Cancer Center. The goal of this research project is to investigate the molecular mechanisms by which environmental and lifestyle risk factors influence cardiovascular traits and the risk of cardiovascular disease. The researchers will leverage large-scale multi-omics...
This $144,362 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to investigate the immunologic mechanisms underlying the development of Chagas cardiomyopathy, a debilitating heart condition that affects 30-40% of individuals infected with Trypanosoma cruzi. The research will use advanced techniques like single-cell RNA sequencing and spatial transcriptomics to characterize the immune cell...