Mechanisms of obesity-induced atrial fibrillation
Active Project Grant Awarded Last action
- Award ID
- R01HL177651
- Recipient
-
Weill Medical College Of Cornell University UEI YNT8TCJH8FQ8
- Awarding agency
-
National Heart Lung and Blood Institute
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,208,572
Award facts
- Assistance listing
- 93.837 Cardiovascular Diseases Research
- Completion date 46% complete
- Place of performance
- New York, NY 10065, USA
Award details come from USAspending.gov.
Description
- Abstract
- Atrial fibrillation (AF) is the most common sustained arrhythmia with approximately one quarter of all adults developing AF by the age of 80. AF can be symptomatic with people experiencing palpitations, racing heart, syncope, congestive heart failure, and cardioembolic stroke. Epidemiologically, aging is associated with AF and increasing obesity confers a stepwise higher lifetime risk of AF. Atrial myopathy and AF are thus expected to become more rampant with the obesity and type 2 diabetes epidemics and the aging population. The molecular mechanism(S) by which obesity leads to atrial fibrillation is poorly understood. We have developed a new mouse model of spontaneous atrial fibrillation triggered by obesity. We found that nicotinamide adenine dinucleotide (NAD+) and the ATF6 ER stress pathway are perturbed in obesity-induced atrial fibrillation. Importantly, correcting NAD+ levels in the heart ameliorates atrial fibrillation. In this proposal, we seek to follow up on these studies and assess the mechanisms by which NAD+ pathways protect against atrial fibrillation. We will pursue the following specific aims: 1. Dissect the role of the NAD+ pathway in obesity- induced AF. 2. Assess the role of the ATF6 ER stress pathway in obesity-induced AF. The overall goal of these studies is to gain greater insight into the molecular pathogenesis of metabolic diseases and AF that may ultimately lead to new treatments to prevent or ameliorate AF.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $22,365 | |
| Amendment | $708,223 | |
| Amendment | $708,223 | |
| Original award | $769,761 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The Trustees Of Columbia University In The City Of New York | $133,244 |
Quick answers
Who received award R01HL177651?
R01HL177651 was awarded to Weill Medical College Of Cornell University by National Heart Lung and Blood Institute (National Institutes of Health) on January 22, 2025.
How much is award R01HL177651 worth?
$2,208,572 has been obligated on R01HL177651.
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