Project Grant R01HL177528
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Children's Hospital of Philadelphia a $180,174 Project Grant effective August 1, 2025, through July 31, 2030, under the Cardiovascular Diseases Research program (CFDA 93.837). This award supports the development of an improved framework for designing next-generation pediatric acute respiratory distress syndrome (ARDS) clinical trials. The research addresses limitations in current trial methodologies...
- Federal Project Grant Award Summary Boston Children's Hospital received an $833,594 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 1, 2025, with a completion date of May 31, 2029. The grant funds basic research investigating the pro-regenerative potential of PONTIN (an AAA+ ATPase protein) in cardiac tissue, with the objective of identifying druggable pathways to stimulate heart...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Maryland, Baltimore a $777,016 Project Grant on August 1, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to support research through May 31, 2029. This project aims to deliver functional characterization and validation of genetic variants associated with hypoplastic heart syndrome (HHS), a severe congenital heart disease affecting approximately 1 in 5,000...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $865,286 to Boston Children's Hospital (The Children's Hospital Corporation) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with a completion date of June 30, 2029. This research initiative will produce a high-resolution spatiotemporal lineage map of cardiac development by integrating advanced lineage tracing, spatial, and single-cell...
- Federal Grant Award Summary The University of Arkansas, Fayetteville Division, received a $414,982 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025 through July 31, 2028. This award supports the development and validation of a force-validated computational model of the human mitral valve designed to improve surgical planning and intelligent device development. The project...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Children's Hospital of Philadelphia Research Institute a $445,000 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) for a three-year period from July 15, 2025, through June 30, 2028. This award supports research determining genetic mechanisms that drive in vitro hematopoiesis, specifically investigating how the tropomyosin 1 (TPM1) gene impacts the development of...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Children's Hospital of Philadelphia Research Institute a $594,583 Project Grant effective August 10, 2025, through May 31, 2029, under the Cardiovascular Diseases Research program (CFDA 93.837). This research project, titled "Origins of Neonatal Lung Myofibroblasts," focuses on advancing understanding of myofibroblast development and function during neonatal lung maturation. The research...
- Federal Grant Award Summary Boston Children's Hospital received a $267,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with completion anticipated by July 31, 2027. The award funds research to identify shared molecular mechanisms underlying congenital heart disease (CHD) and neurodevelopmental delay and disability (NDD) by characterizing dysregulated gene expression in...
- Federal Grant Award Summary New York University School of Medicine received a $165,672 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for August 31, 2030. The award supports research aimed at increasing heart transplant (HT) donor utilization in the United States by addressing two primary research objectives. First, the project will investigate the...
- Federal Project Grant Award Summary The University of Arkansas, Fayetteville received a $546,654 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded May 1, 2026 through January 31, 2030. The project delivers computational and experimental products designed to advance cardiac fibrosis prediction and therapeutic intervention for heart failure with reduced ejection fraction (HFrEF) patients. Primary...
The National Heart, Lung, and Blood Institute (NHLBI) awarded Arkansas Children's Research Institute $801,261 under the Cardiovascular Diseases Research program (CFDA 93.837) for a project addressing pediatric heart valve replacement challenges through partial heart transplantation (PHT). The project, initiated May 1, 2026 and concluding February 28, 2031, focuses on advancing the scientific evidence base for clinical protocols tailored to children receiving PHT. Unlike conventional heart transplantation (HT), PHT preserves the recipient's native ventricles while transplanting only the valve-containing heart section, theoretically enabling adaptive growth with the child and eliminating the need for serial re-operations to replace outgrown implants. The research will deliver critical knowledge regarding PHT transplant biology that currently remains unexplored, representing a significant barrier to clinical protocol development. The project deliverables include research findings across three specific aims investigating clinically relevant aspects of PHT transplant biology: examination of donor ischemia time effects, assessment of immunosuppression requirements, and evaluation of ABO-incompatible transplantation feasibility. The research will leverage a unique piglet model and innovative echocardiographic outcome measures for valve growth assessment. These research products will contribute the evidence base necessary to move beyond empirically applying HT clinical protocols to children with PHT and establish specialized clinical protocols that maximize therapeutic outcomes while reducing procedural burden for pediatric transplant recipients.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $801.3k | 5/4/26 |